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Q5WVN0

- PYRD_LEGPL

UniProt

Q5WVN0 - PYRD_LEGPL

Protein

Dihydroorotate dehydrogenase (quinone)

Gene

pyrD

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.UniRule annotation

    Catalytic activityi

    (S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

    Cofactori

    Binds 1 FMN per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei60 – 601SubstrateUniRule annotation
    Binding sitei80 – 801FMN; via amide nitrogenUniRule annotation
    Binding sitei133 – 1331FMNUniRule annotation
    Binding sitei166 – 1661FMNUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Active sitei169 – 1691NucleophileUniRule annotation
    Binding sitei171 – 1711SubstrateUniRule annotation
    Binding sitei211 – 2111FMNUniRule annotation
    Binding sitei239 – 2391FMN; via carbonyl oxygenUniRule annotation
    Binding sitei262 – 2621FMN; via amide nitrogenUniRule annotation
    Binding sitei291 – 2911FMN; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 605FMNUniRule annotation
    Nucleotide bindingi312 – 3132FMNUniRule annotation

    GO - Molecular functioni

    1. dihydroorotate oxidase activity Source: InterPro

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Keywords - Ligandi

    Flavoprotein, FMN

    Enzyme and pathway databases

    BioCyciLPNE297245:GJD4-1915-MONOMER.
    UniPathwayiUPA00070; UER00946.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroorotate dehydrogenase (quinone)UniRule annotation (EC:1.3.5.2UniRule annotation)
    Alternative name(s):
    DHOdehaseUniRule annotation
    Short name:
    DHODUniRule annotation
    Short name:
    DHODaseUniRule annotation
    Dihydroorotate oxidaseUniRule annotation
    Gene namesi
    Name:pyrDUniRule annotation
    Ordered Locus Names:lpl1785
    OrganismiLegionella pneumophila (strain Lens)
    Taxonomic identifieri297245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000002517: Chromosome

    Organism-specific databases

    LegioListilpl1785.

    Subcellular locationi

    Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333Dihydroorotate dehydrogenase (quinone)PRO_0000148450Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi297245.lpl1785.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WVN0.
    SMRiQ5WVN0. Positions 2-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni105 – 1095Substrate bindingUniRule annotation
    Regioni240 – 2412Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0167.
    HOGENOMiHOG000225103.
    KOiK00254.
    OMAiWEAIADI.
    OrthoDBiEOG65BDN8.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00225. DHO_dh_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view]
    PfamiPF01180. DHO_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
    PROSITEiPS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5WVN0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYSLLRPLLF RLDAEKAHSL TLSLLHYLPG FYFRKMAGQP VHAMGLVFPH    50
    QVGLAAGLDK NGEHLDALAK LGFSFIELGT VTPKGQTGNP KPRLFRIAEA 100
    NAIINRMGFN NSGVDVLVEN VKSANYKGIL GINIGKNKET NLNQAADDYL 150
    YCFRKVYDHA SYVTINISSP NTPDLRQLQQ GDYFAELLAQ LQKEQIKLAD 200
    QYGRHVPLVV KVSPDETDET LKQMTDIILQ YGIEGIIATN TTCSREMVKN 250
    LPCSEEQGGL SGRPLMELST RCLRLLKQYV GNDVTLIGVG GIDSLESAKD 300
    KINAGASLLQ VYSGLVYKGP ELIHDIVSGL NAV 333
    Length:333
    Mass (Da):36,579
    Last modified:November 23, 2004 - v1
    Checksum:i9110AA902B8BBD1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628337 Genomic DNA. Translation: CAH16024.1.
    RefSeqiWP_011215792.1. NC_006369.1.
    YP_127123.1. NC_006369.1.

    Genome annotation databases

    EnsemblBacteriaiCAH16024; CAH16024; lpl1785.
    GeneIDi3115233.
    KEGGilpf:lpl1785.
    PATRICi22317287. VBILegPne33733_1970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628337 Genomic DNA. Translation: CAH16024.1 .
    RefSeqi WP_011215792.1. NC_006369.1.
    YP_127123.1. NC_006369.1.

    3D structure databases

    ProteinModelPortali Q5WVN0.
    SMRi Q5WVN0. Positions 2-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297245.lpl1785.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH16024 ; CAH16024 ; lpl1785 .
    GeneIDi 3115233.
    KEGGi lpf:lpl1785.
    PATRICi 22317287. VBILegPne33733_1970.

    Organism-specific databases

    LegioListi lpl1785.

    Phylogenomic databases

    eggNOGi COG0167.
    HOGENOMi HOG000225103.
    KOi K00254.
    OMAi WEAIADI.
    OrthoDBi EOG65BDN8.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00946 .
    BioCyci LPNE297245:GJD4-1915-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00225. DHO_dh_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR012135. Dihydroorotate_DH_1_2.
    IPR005719. Dihydroorotate_DH_2.
    IPR001295. Dihydroorotate_DH_CS.
    [Graphical view ]
    Pfami PF01180. DHO_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000164. DHO_oxidase. 1 hit.
    TIGRFAMsi TIGR01036. pyrD_sub2. 1 hit.
    PROSITEi PS00911. DHODEHASE_1. 1 hit.
    PS00912. DHODEHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Lens.

    Entry informationi

    Entry nameiPYRD_LEGPL
    AccessioniPrimary (citable) accession number: Q5WVN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3