Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5WV09 (SYR_LEGPL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:lpl2008
OrganismLegionella pneumophila (strain Lens) [Complete proteome] [HAMAP]
Taxonomic identifier297245 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length589 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 589589Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242037

Regions

Motif131 – 14111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5WV09 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 86513C13E1E82041

FASTA58965,878
        10         20         30         40         50         60 
MRSMKAIIEY LLKQALINLQ QSGEMPIDLE IEIKVENAKD PAHGDYATNL ALVLAKPCRQ 

        70         80         90        100        110        120 
APKVLAERLV AVIPADPSVE KIEIAGAGFI NFFMRSTARS LIISEILNKG KEFGQGNLGQ 

       130        140        150        160        170        180 
SQKVLIEFVS ANPTGPLHVG HGRGAAFGAT LGNVLKAAGY DVTLEYYVND AGRQMNILAV 

       190        200        210        220        230        240 
SVWLRYLELA GEPIAFPANG YKGQYVYEIA QEMWSEQGNQ FVHPWISVVD NLPADEPEGG 

       250        260        270        280        290        300 
DKETYIDAII ARAQSLLGKD GFANFHQHAL KTVLDDIKDD LQAFGVRFDS WFSEQSLFED 

       310        320        330        340        350        360 
GSIGKGIQAL KDRGHTYERE GALWFRATDF GDEKDRVLVR ANGQTTYFAS DVAYHWNKYD 

       370        380        390        400        410        420 
RGFDRVIDIF GADHHGYVTR IKTAVKALGH DESALDVILV QFAILYRGGD RVQMSTRSGS 

       430        440        450        460        470        480 
FVTLRELREE VGNDAARYFY VARKPEQHMD FDLDLAKSES SDNPVYYIQY AHARICSVLR 

       490        500        510        520        530        540 
QLKERGLKWD KDMGLKNLDL LEQQHEATLI SLIARYPEVI QSAAASCEPH QLAYYLRELA 

       550        560        570        580 
NGLHSYYNAI QLLCEQEQLR CARLCLLESV RQVLNNGLAI LGVSAPESM 

« Hide

References

[1]"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Lens.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR628337 Genomic DNA. Translation: CAH16248.1.
RefSeqYP_127344.1. NC_006369.1.

3D structure databases

ProteinModelPortalQ5WV09.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING297245.lpl2008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH16248; CAH16248; lpl2008.
GeneID3114792.
KEGGlpf:lpl2008.
PATRIC22317777. VBILegPne33733_2205.

Organism-specific databases

LegioListlpl2008.
CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycLPNE297245:GJD4-2163-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 2 hits.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_LEGPL
AccessionPrimary (citable) accession number: Q5WV09
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries