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Protein

UvrABC system protein C

Gene

uvrC

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein CUniRule annotation
Short name:
Protein UvrCUniRule annotation
Alternative name(s):
Excinuclease ABC subunit CUniRule annotation
Gene namesi
Name:uvrCUniRule annotation
Ordered Locus Names:lpl2570
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000002517 Componenti: Chromosome

Organism-specific databases

LegioListilpl2570.

Subcellular locationi

Q5WTF5:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002274411 – 618UvrABC system protein CAdd BLAST618

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5WTF5.
SMRiQ5WTF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 97GIY-YIGUniRule annotationAdd BLAST79
Domaini208 – 243UVRUniRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000279961.
KOiK03703.
OMAiLFPIRQC.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WTF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDLQLSAEL ALFLTKLPSE PGIYRMLDEE GTVLYVGKAA NLKKRVNSYF
60 70 80 90 100
SKQNTGVKTR ALVSQIKSIE ISVTRSETEA LLLESNLIKA LRPKYNVLLR
110 120 130 140 150
DDKSYPYIHL SNHPDFPRVE LYRSKKKPPS GNFFGPYPGV AAVRETIVTI
160 170 180 190 200
QKIFKIRNCR DSYFKARSRP CLQYQIKRCT APCVHYISPE NYKLSVEDAI
210 220 230 240 250
RFLQGKCQII LDELAERMKN AVSQLNFEEA AVLRDQIKNL RLIQEQQGVV
260 270 280 290 300
QLRGDADVIA IEVRPGFACI QCVTIREGQV LNSQSFFPTV PYAVLDEELD
310 320 330 340 350
ANSLWQQTFE AFIGFYYLDT SERIPDLIIT NQSITESRSL EYILSQRRGK
360 370 380 390 400
SCKIQVNPRG VKSRWMDFAV NNLRISVAEY VSKHSTIRSR YQALRQLLAL
410 420 430 440 450
DKNIERMECF DISHTQGEAT VASCVVFDTE GPRPSEYRRF NIEGITPGDD
460 470 480 490 500
YAAMEQAVTR RFKRLIGAQL LPDVLIIDGG KGQVSIVKRV LTSLGVEDIT
510 520 530 540 550
LLGVSKGPSR KAGWEKLILV NENREFVLPE DSKALHLLQH IRDEAHRFAI
560 570 580 590 600
TAHRKKRQKT RVESTLESIE GVGAKRRQAL LQRFGGLREL AKASLEEICK
610
VQGISEQLAK RIYEHFHP
Length:618
Mass (Da):70,396
Last modified:November 23, 2004 - v1
Checksum:i6AB8732EF54B8379
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA. Translation: CAH16811.1.
RefSeqiWP_011216517.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH16811; CAH16811; lpl2570.
KEGGilpf:lpl2570.

Similar proteinsi

Entry informationi

Entry nameiUVRC_LEGPL
AccessioniPrimary (citable) accession number: Q5WTF5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families