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Q5WSY8

- NADK_LEGPL

UniProt

Q5WSY8 - NADK_LEGPL

Protein

NAD kinase

Gene

nadK

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Proton acceptorUniRule annotation
    Binding sitei159 – 1591NADUniRule annotation
    Binding sitei176 – 1761NADUniRule annotation
    Binding sitei178 – 1781NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 752NADUniRule annotation
    Nucleotide bindingi148 – 1492NADUniRule annotation
    Nucleotide bindingi189 – 1946NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLPNE297245:GJD4-2969-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:lpl2738
    OrganismiLegionella pneumophila (strain Lens)
    Taxonomic identifieri297245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000002517: Chromosome

    Organism-specific databases

    LegioListilpl2738.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295NAD kinasePRO_0000229649Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi297245.lpl2738.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WSY8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227221.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5WSY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRKFKRAIL YARQHRANQE VNESLHRLVD FLSTQDIEIF QDSDTAASFE    50
    LKAPVLPREK MGAKHDLIIV VGGDGSLLSA SRMAIKVNAP VIGINRGRLG 100
    FLTDILPQDI ESHLGPVLNG QYNEEERFLL HTKIYDKENS YFEGDALNDV 150
    VLGRGSETHL IEFDVYINQQ LVSHYRSDGM ILSTPTGSTA YALSAGGPIM 200
    HPQLNAIVLV PMFSHSLSSR PLVIDGEAEI ELYISKSNET DLRISCDGHE 250
    SRVVKPGQKV AVKKNGNRLR LLHPLDYHYY DTLRSKLGWE SKHQG 295
    Length:295
    Mass (Da):33,088
    Last modified:November 23, 2004 - v1
    Checksum:i375BE2CD7201C99A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628337 Genomic DNA. Translation: CAH16981.1.
    RefSeqiYP_128065.1. NC_006369.1.

    Genome annotation databases

    EnsemblBacteriaiCAH16981; CAH16981; lpl2738.
    GeneIDi3116206.
    KEGGilpf:lpl2738.
    PATRICi22319400. VBILegPne33733_3001.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628337 Genomic DNA. Translation: CAH16981.1 .
    RefSeqi YP_128065.1. NC_006369.1.

    3D structure databases

    ProteinModelPortali Q5WSY8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297245.lpl2738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH16981 ; CAH16981 ; lpl2738 .
    GeneIDi 3116206.
    KEGGi lpf:lpl2738.
    PATRICi 22319400. VBILegPne33733_3001.

    Organism-specific databases

    LegioListi lpl2738.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227221.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci LPNE297245:GJD4-2969-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Lens.

    Entry informationi

    Entry nameiNADK_LEGPL
    AccessioniPrimary (citable) accession number: Q5WSY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3