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Protein

NAD kinase

Gene

nadK

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Proton acceptorUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei176NADUniRule annotation1
Binding sitei178NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 75NADUniRule annotation2
Nucleotide bindingi148 – 149NADUniRule annotation2
Nucleotide bindingi189 – 194NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:lpl2738
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
Proteomesi
  • UP000002517 Componenti: Chromosome

Organism-specific databases

LegioListilpl2738

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296491 – 295NAD kinaseAdd BLAST295

Structurei

3D structure databases

ProteinModelPortaliQ5WSY8
SMRiQ5WSY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WSY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKFKRAIL YARQHRANQE VNESLHRLVD FLSTQDIEIF QDSDTAASFE
60 70 80 90 100
LKAPVLPREK MGAKHDLIIV VGGDGSLLSA SRMAIKVNAP VIGINRGRLG
110 120 130 140 150
FLTDILPQDI ESHLGPVLNG QYNEEERFLL HTKIYDKENS YFEGDALNDV
160 170 180 190 200
VLGRGSETHL IEFDVYINQQ LVSHYRSDGM ILSTPTGSTA YALSAGGPIM
210 220 230 240 250
HPQLNAIVLV PMFSHSLSSR PLVIDGEAEI ELYISKSNET DLRISCDGHE
260 270 280 290
SRVVKPGQKV AVKKNGNRLR LLHPLDYHYY DTLRSKLGWE SKHQG
Length:295
Mass (Da):33,088
Last modified:November 23, 2004 - v1
Checksum:i375BE2CD7201C99A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR628337 Genomic DNA Translation: CAH16981.1
RefSeqiWP_011216663.1, NC_006369.1

Genome annotation databases

EnsemblBacteriaiCAH16981; CAH16981; lpl2738
KEGGilpf:lpl2738

Similar proteinsi

Entry informationi

Entry nameiNADK_LEGPL
AccessioniPrimary (citable) accession number: Q5WSY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: June 20, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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