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Q5WSK6

- LPXB2_LEGPL

UniProt

Q5WSK6 - LPXB2_LEGPL

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Protein

Lipid-A-disaccharide synthase 2

Gene

lpxB2

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciLPNE297245:GJD4-3113-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase 2UniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxB2UniRule annotation
Ordered Locus Names:lpl2872
OrganismiLegionella pneumophila (strain Lens)
Taxonomic identifieri297245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000002517: Chromosome

Organism-specific databases

LegioListilpl2872.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385Lipid-A-disaccharide synthase 2PRO_0000255191Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi297245.lpl2872.

Structurei

3D structure databases

ProteinModelPortaliQ5WSK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiEWTINPP.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WSK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKKRQTRIA MIAGEMSGDL LGAGVIRELK KHLKNVEFIG VGGPQMLEEG
60 70 80 90 100
FQSLANMSEL SVMGISDVLR RYPQLYFIRE RLLKEWTINP PDVFIGIDYP
110 120 130 140 150
DFNLSVETRL KRQNVKTVHL VSPKVWAWRQ KRVYLIKKAV DLVLTLFPFE
160 170 180 190 200
ESFYQQYDVP AQFVGHPLAD LIEINPNNAD LRKKYNYKPD DTILAVLPGS
210 220 230 240 250
RIGEIKYIGP LFLEVMQRIA VEMPHVHFIV PIACQELYPV FFKQFQARYS
260 270 280 290 300
HLKIQIIQGN AREAMAISDV VLTKSGTATL EAMLLKRPMV VAFKWSKFTH
310 320 330 340 350
AIIAPQVKIP YVALPNLLAN KKLVPEFVQE KATANSITES VLNLLACPSQ
360 370 380
SNLNKQFTAI HHTLRQNANE KAALSILKIL ETSSA
Length:385
Mass (Da):43,707
Last modified:November 23, 2004 - v1
Checksum:i1D98923F1C9B3E5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628337 Genomic DNA. Translation: CAH17116.1.
RefSeqiWP_011216786.1. NC_006369.1.
YP_128197.1. NC_006369.1.

Genome annotation databases

EnsemblBacteriaiCAH17116; CAH17116; lpl2872.
GeneIDi3113886.
KEGGilpf:lpl2872.
PATRICi22319702. VBILegPne33733_3152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR628337 Genomic DNA. Translation: CAH17116.1 .
RefSeqi WP_011216786.1. NC_006369.1.
YP_128197.1. NC_006369.1.

3D structure databases

ProteinModelPortali Q5WSK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 297245.lpl2872.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH17116 ; CAH17116 ; lpl2872 .
GeneIDi 3113886.
KEGGi lpf:lpl2872.
PATRICi 22319702. VBILegPne33733_3152.

Organism-specific databases

LegioListi lpl2872.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi EWTINPP.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci LPNE297245:GJD4-3113-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
    Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
    Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Lens.

Entry informationi

Entry nameiLPXB2_LEGPL
AccessioniPrimary (citable) accession number: Q5WSK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3