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Q5WSK6

- LPXB2_LEGPL

UniProt

Q5WSK6 - LPXB2_LEGPL

Protein

Lipid-A-disaccharide synthase 2

Gene

lpxB2

Organism
Legionella pneumophila (strain Lens)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciLPNE297245:GJD4-3113-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase 2UniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxB2UniRule annotation
    Ordered Locus Names:lpl2872
    OrganismiLegionella pneumophila (strain Lens)
    Taxonomic identifieri297245 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000002517: Chromosome

    Organism-specific databases

    LegioListilpl2872.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Lipid-A-disaccharide synthase 2PRO_0000255191Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi297245.lpl2872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WSK6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiEWTINPP.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5WSK6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKKRQTRIA MIAGEMSGDL LGAGVIRELK KHLKNVEFIG VGGPQMLEEG    50
    FQSLANMSEL SVMGISDVLR RYPQLYFIRE RLLKEWTINP PDVFIGIDYP 100
    DFNLSVETRL KRQNVKTVHL VSPKVWAWRQ KRVYLIKKAV DLVLTLFPFE 150
    ESFYQQYDVP AQFVGHPLAD LIEINPNNAD LRKKYNYKPD DTILAVLPGS 200
    RIGEIKYIGP LFLEVMQRIA VEMPHVHFIV PIACQELYPV FFKQFQARYS 250
    HLKIQIIQGN AREAMAISDV VLTKSGTATL EAMLLKRPMV VAFKWSKFTH 300
    AIIAPQVKIP YVALPNLLAN KKLVPEFVQE KATANSITES VLNLLACPSQ 350
    SNLNKQFTAI HHTLRQNANE KAALSILKIL ETSSA 385
    Length:385
    Mass (Da):43,707
    Last modified:November 23, 2004 - v1
    Checksum:i1D98923F1C9B3E5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628337 Genomic DNA. Translation: CAH17116.1.
    RefSeqiYP_128197.1. NC_006369.1.

    Genome annotation databases

    EnsemblBacteriaiCAH17116; CAH17116; lpl2872.
    GeneIDi3113886.
    KEGGilpf:lpl2872.
    PATRICi22319702. VBILegPne33733_3152.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR628337 Genomic DNA. Translation: CAH17116.1 .
    RefSeqi YP_128197.1. NC_006369.1.

    3D structure databases

    ProteinModelPortali Q5WSK6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 297245.lpl2872.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH17116 ; CAH17116 ; lpl2872 .
    GeneIDi 3113886.
    KEGGi lpf:lpl2872.
    PATRICi 22319702. VBILegPne33733_3152.

    Organism-specific databases

    LegioListi lpl2872.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi EWTINPP.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci LPNE297245:GJD4-3113-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity."
      Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.
      Nat. Genet. 36:1165-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Lens.

    Entry informationi

    Entry nameiLPXB2_LEGPL
    AccessioniPrimary (citable) accession number: Q5WSK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3