Q5WQZ9 (KBX34_OPICA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Opiscorpine-4
Organism	Opistophthalmus carinatus (African yellow leg scorpion)
Taxonomic identifier	190115 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Scorpionidae › Scorpioninae › Opistophthalmus

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antimicrobial activity against yeasts and bacteria By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long chain scorpion toxin family. Class 3 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Fungicide
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW defense response to fungus Inferred from electronic annotation. Source: UniProtKB-KW killing of cells of other organism Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 95	76	Opiscorpine-4		PRO_5000092274
Amino acid modifications
	Disulfide bond	58 ↔ 82		By similarity
	Disulfide bond	68 ↔ 87		By similarity
	Disulfide bond	72 ↔ 89		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WQZ9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 95EFA86F1CB9475F	FASTA	95	10,397
	10 20 30 40 50 60 MNNKLTALIF LGLLAIASCK WLNEKSIQNK IDEKIGKNFL GGMAKAVVHK LAKNEFMCVA 70 80 90 NIDMTKSCDT HCQKASGEKG YCHGTKCKCG VPLSY

References

[1]	"The scorpine family of defensins: gene structure, alternative polyadenylation and fold recognition." Zhu S., Tytgat J. Cell. Mol. Life Sci. 61:1751-1763(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY423485 mRNA. Translation: AAQ94356.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

KBX34_OPICA

Accession

Primary (citable) accession number: Q5WQZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	November 23, 2004
Last modified:	October 3, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)