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Q5WNX2

- UPPP2_ENTFL

UniProt

Q5WNX2 - UPPP2_ENTFL

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Enterococcus faecalis (Streptococcus faecalis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.By similarity

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase (EC:3.6.1.27)
    Alternative name(s):
    Bacitracin resistance protein
    Undecaprenyl pyrophosphate phosphatase
    Gene namesi
    Name:uppP
    Synonyms:bcrD
    Encoded oniPlasmid pJM010 Publication
    OrganismiEnterococcus faecalis (Streptococcus faecalis)
    Taxonomic identifieri1351 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatasePRO_0000151150Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei6 – 2621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei89 – 10921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei117 – 13721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5WNX2-1 [UniParc]FASTAAdd to Basket

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    MALDFIEILK VIFLGIVEGI TEWLPISSTG HMLLVDEFIT LNMSEAFKEM    50
    FFVVIQLGAI LAVVVMFWNK MFPFQFKNKS QSIIKKDTFS LWFKVAVACV 100
    PSAIMGILFD DYLDAHLHTP VVIAIMLILY GVLFIVIENR NKKRTATTST 150
    LADISYKTAL MIGVFQVLSL IPGTSRSGAT IIGALLIGVS RVAAAEFTFF 200
    LAVPTMLGAS AFKLLKFGFD FTSAELLTLV IGMAVAFAVS VFVIKFLMSY 250
    IKKHDFKVFG WYRIVLGILV LLITAI 276
    Length:276
    Mass (Da):30,622
    Last modified:November 23, 2004 - v1
    Checksum:i70FC7B0C571ED6B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY496968 Genomic DNA. Translation: AAS78449.1.
    RefSeqiWP_002367748.1. NC_014726.1.
    YP_004032990.1. NC_014726.1.

    Genome annotation databases

    GeneIDi9988300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY496968 Genomic DNA. Translation: AAS78449.1 .
    RefSeqi WP_002367748.1. NC_014726.1.
    YP_004032990.1. NC_014726.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9988300.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR."
      Manson J.M., Keis S., Smith J.M.B., Cook G.M.
      Antimicrob. Agents Chemother. 48:3743-3748(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AR01/DGVS.

    Entry informationi

    Entry nameiUPPP2_ENTFL
    AccessioniPrimary (citable) accession number: Q5WNX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3