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Q5WNX2 (UPPP2_ENTFL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bcrD
Encoded onPlasmid pJM01
OrganismEnterococcus faecalis (Streptococcus faecalis)
Taxonomic identifier1351 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151150

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane49 – 6921Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane181 – 20121Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane256 – 27621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5WNX2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 70FC7B0C571ED6B7

FASTA27630,622
        10         20         30         40         50         60 
MALDFIEILK VIFLGIVEGI TEWLPISSTG HMLLVDEFIT LNMSEAFKEM FFVVIQLGAI 

        70         80         90        100        110        120 
LAVVVMFWNK MFPFQFKNKS QSIIKKDTFS LWFKVAVACV PSAIMGILFD DYLDAHLHTP 

       130        140        150        160        170        180 
VVIAIMLILY GVLFIVIENR NKKRTATTST LADISYKTAL MIGVFQVLSL IPGTSRSGAT 

       190        200        210        220        230        240 
IIGALLIGVS RVAAAEFTFF LAVPTMLGAS AFKLLKFGFD FTSAELLTLV IGMAVAFAVS 

       250        260        270 
VFVIKFLMSY IKKHDFKVFG WYRIVLGILV LLITAI 

« Hide

References

[1]"Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR."
Manson J.M., Keis S., Smith J.M.B., Cook G.M.
Antimicrob. Agents Chemother. 48:3743-3748(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AR01/DGVS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY496968 Genomic DNA. Translation: AAS78449.1.
RefSeqYP_004032990.1. NC_014726.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9988300.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_ENTFL
AccessionPrimary (citable) accession number: Q5WNX2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families