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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921ATPUniRule annotation
Binding sitei126 – 1261ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 315ATPUniRule annotation
Nucleotide bindingi177 – 1815ATPUniRule annotation
Nucleotide bindingi208 – 2136ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:ABC0120
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Protein-arginine kinasePRO_1000025870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC0120.

Structurei

3D structure databases

ProteinModelPortaliQ5WLU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 255232Phosphagen kinase C-terminalUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiNESMLRI.
OrthoDBiEOG6NKR1D.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WLU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDRFLKNA ISPWMKKDGS DADIVLSSRI RLARNMSAFT FPMLSSKEEA
60 70 80 90 100
YAVAKHVKDA LGGTQGEALG KAEMLAMEDM RTNDKRMLVE KHLISPHLAE
110 120 130 140 150
QSKYGMVLLS GDESLSIMIN EEDHIRIQSL SAGFELENCL QAANAVDDWV
160 170 180 190 200
ESHLTYAYDS QYGYLTSCPT NVGTGMRASV MIHLPALAMT RQLQRILPAI
210 220 230 240 250
NQLGLVVRGI YGEGSEALGN LFQISNQITL GKTEQDIVDD LQGVVKQLIR
260 270 280 290 300
QERVARDSLL QHSKLELKDR VFRSYGILAN SYIIDSKEAT RRLSDVRLGI
310 320 330 340 350
DLGFIENTAG KILDELMILT QPGFLQQYAK TVLTPEQRDE RRAALIRERL

KLEHETAD
Length:358
Mass (Da):40,099
Last modified:November 23, 2004 - v1
Checksum:iA42376DAA1739DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD62663.1.
RefSeqiWP_011244984.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD62663; BAD62663; ABC0120.
KEGGibcl:ABC0120.
PATRICi18919420. VBIBacCla58185_0127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD62663.1.
RefSeqiWP_011244984.1. NC_006582.1.

3D structure databases

ProteinModelPortaliQ5WLU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi66692.ABC0120.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD62663; BAD62663; ABC0120.
KEGGibcl:ABC0120.
PATRICi18919420. VBIBacCla58185_0127.

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiNESMLRI.
OrthoDBiEOG6NKR1D.

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-142-MONOMER.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiMCSB_BACSK
AccessioniPrimary (citable) accession number: Q5WLU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: January 20, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.