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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei595For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:ABC0245
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

Subcellular locationi

Q5WLG7:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001352992 – 600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST599

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC0245.

Structurei

3D structure databases

ProteinModelPortaliQ5WLG7.
SMRiQ5WLG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 217Glutamine amidotransferase type-2UniRule annotationAdd BLAST216
Domaini283 – 422SIS 1UniRule annotationAdd BLAST140
Domaini452 – 590SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5WLG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGN EDAKEILLSG LEKLEYRGYD SAGIAVRTES DTEVFKEKGR
60 70 80 90 100
IATLRKAVDE NVHSTVGIGH TRWATHGVPS QLNAHPHQSA TERYTLVHNG
110 120 130 140 150
VIENYEQIKR DYLADVQLKS DTDTEVIVQF IEQLAGEGLT TEEAVSKALS
160 170 180 190 200
LMKGSYAIAL LDKDDPDTIF VGKNKSPLLV GVGENANVVA SDAMAMLTVT
210 220 230 240 250
DQFIEIMDEE LVIVRRDRIE IKTLAGDVQE RKPYTAELDV SDIEKGTYAH
260 270 280 290 300
FMLKEIDEQP FVIRNIIQKY QHEDGSTRLD EDIRAAMKDS DRIYIVAAGT
310 320 330 340 350
SYHAGLVGKQ LLERVSGKPT EVHIASEFLY NMPLLSEKPL FVFISQSGET
360 370 380 390 400
ADSRGVLVNV KKQGHRTLTI TNVPGSTLSR EADYTLHTFA GPEIAVASTK
410 420 430 440 450
AYTAQIAVLA LLAVDVANAA GKTLDFDLLQ ELAIAANAME SLCNQKDEME
460 470 480 490 500
QIARDYLSVT RNAFFIGRTA DYFVALEGAL KLKEISYIQA EGFAGGELKH
510 520 530 540 550
GTIALIEDGT PVIALATQEH VNLSIRGNVQ EVASRGAATA IISMEGLDQE
560 570 580 590 600
GDAVVLPRVH ELLTPLVSVI PTQLIAYYAA LHRGCDVDKP RNLAKSVTVE
Length:600
Mass (Da):65,587
Last modified:January 23, 2007 - v3
Checksum:i47841E1A78D02E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD62788.1.
RefSeqiWP_011245108.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD62788; BAD62788; ABC0245.
KEGGibcl:ABC0245.

Similar proteinsi

Entry informationi

Entry nameiGLMS_BACSK
AccessioniPrimary (citable) accession number: Q5WLG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 88 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome