Q5WKZ1 (IOLA1_BACSK) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 54.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Methylmalonate semialdehyde dehydrogenase [acylating] 1 Short name=MMSA dehydrogenase 1 Short name=MMSDH 1 Short name=MSDH 1 EC=1.2.1.27 Alternative name(s): Malonate semialdehyde dehydrogenase [acetylating] 1 Short name=MSA dehydrogenase 1 EC=1.2.1.18 | ||||
| Gene names |
| ||||
| Organism | Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 66692 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 491 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP MF_01670 |
| Catalytic activity | 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP MF_01670 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP MF_01670 |
| Pathway | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP MF_01670 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01670 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. IolA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | malonate-semialdehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC methylmalonate-semialdehyde dehydrogenase (acylating) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 491 | 491 | Methylmalonate semialdehyde dehydrogenase [acylating] 1 HAMAP MF_01670 | PRO_0000352326 | |||||
Regions | |||||||||
| Nucleotide binding | 180 – 184 | 5 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 288 | 1 | Nucleophile By similarity | ||||||
| Binding site | 386 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AP006627 Genomic DNA. Translation: BAD62964.1. |
| RefSeq | YP_173925.1. NC_006582.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1T90 based on UniProtKB P42412. |
| ProteinModelPortal | Q5WKZ1. |
| SMR | Q5WKZ1. Positions 7-490. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5WKZ1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000047184; EBBACP00000045945; EBBACG00000047175. |
| GeneID | 3201317. |
| GenomeReviews | Gene locus ABC0422 in contig AP006627_GR. |
| KEGG | bcl:ABC0422. |
| NMPDR | fig|66692.3.peg.325. |
| PATRIC | 18920072. VBIBacCla58185_0441. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1012. |
| GeneTree | EBGT00070000031871. |
| HOGENOM | HBG752218. |
| OMA | YAEGTRR. |
| ProtClustDB | CLSK2460970. |
Enzyme and pathway databases | |
| BioCyc | BCLA66692:ABC0422-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01670. IolA. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR010061. MeMal-semiAld_DH. IPR023510. MeMal-semiAld_DH_GmP_bac. [Graphical view] |
| Gene3D | G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| KO | K00140. |
| PANTHER | PTHR11699:SF27. MMSDH. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR01722. MMSDH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IOLA1_BACSK | ||||||||
| Accession | Primary (citable) accession number: Q5WKZ1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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