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Protein

5-deoxy-glucuronate isomerase

Gene

iolB

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the isomerization of 5-deoxy-glucuronate (5DG) to 5-dehydro-2-deoxy-D-gluconate (DKG or 2-deoxy-5-keto-D-gluconate).UniRule annotation

Catalytic activityi

5-deoxy-D-glucuronate = 5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 4 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (iolG)
  2. Inosose dehydratase (iolE)
  3. 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase (iolJ)
  7. Malonate-semialdehyde dehydrogenase 1 (iolA1), Malonate-semialdehyde dehydrogenase 2 (iolA2)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00076; UER00920.

Names & Taxonomyi

Protein namesi
Recommended name:
5-deoxy-glucuronate isomeraseUniRule annotation (EC:5.3.1.30UniRule annotation)
Short name:
5DG isomeraseUniRule annotation
Gene namesi
Name:iolBUniRule annotation
Ordered Locus Names:ABC0423
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003523831 – 2715-deoxy-glucuronate isomeraseAdd BLAST271

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC0423.

Structurei

3D structure databases

ProteinModelPortaliQ5WKZ0.
SMRiQ5WKZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isomerase IolB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3718. LUCA.
HOGENOMiHOG000239754.
KOiK03337.
OMAiHGYDLYY.
OrthoDBiPOG091H0FEO.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_01673. IolB. 1 hit.
InterProiView protein in InterPro
IPR024203. Deoxy-glucuronate_isom_IolB.
IPR023770. IolB_Bacilli.
IPR021120. KduI/IolB_isomerase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin_sf.
PfamiView protein in Pfam
PF04962. KduI. 1 hit.
PIRSFiPIRSF036628. IolB. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR04378. myo_inos_iolB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WKZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQLLKKPKT KVLKQGVTLV HDTEAEKAPL KYVSFKLVDI QANAIYEETL
60 70 80 90 100
GSYECCIVVV RGTVTVTDGE HVFSNIGTRS SVFERKPTDS VYLSNGRSFT
110 120 130 140 150
VTGTSEACIA LCYAPSNKQL PTKLIKASDV GIENRGQLQN KRLVHNILPD
160 170 180 190 200
SDKTANSLLV VEVFTESGNW SSYPPHKHDE DNLPYESFLE ETYYHEIDPP
210 220 230 240 250
QGFVFQRVYT ESRNIDETMA VENGDVVIVP AGYHPVGVPD GYASYYLNVM
260 270
AGPVRIWKFR NEKDHEWILS R
Length:271
Mass (Da):30,452
Last modified:November 23, 2004 - v1
Checksum:i1492C688D632C19C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD62965.1.

Genome annotation databases

EnsemblBacteriaiBAD62965; BAD62965; ABC0423.
KEGGibcl:ABC0423.

Similar proteinsi

Entry informationi

Entry nameiIOLB_BACSK
AccessioniPrimary (citable) accession number: Q5WKZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families