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Q5WKY6 (IOLG_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

EC=1.1.1.18
EC=1.1.1.369
Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase
Gene names
Name:iolG
Ordered Locus Names:ABC0427
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP-Rule MF_01671

Catalytic activity

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671

1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP-Rule MF_01671

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01671

Sequence similarities

Belongs to the Gfo/Idh/MocA family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processinositol catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioninositol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP-Rule MF_01671
PRO_0000352555

Sequences

Sequence LengthMass (Da)Tools
Q5WKY6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 3BBDA0E986095B37

FASTA34638,171
        10         20         30         40         50         60 
MTVRVGVIGT GAIGQDHIRR LECKLSGAKV TAVTDVNQDL ARKVANTYAK QATVYANDRE 

        70         80         90        100        110        120 
LIAARDVDAV LVASWGPAHE ASVLAALEAG KRVFCEKPLA TTADGCMRIV EAEMAHGKRL 

       130        140        150        160        170        180 
VQVGFMRRFD SGYLQLKQAL EQELVGEPLM VRCIHRNVES AESYTTDMAI TDTLIHEIDV 

       190        200        210        220        230        240 
LHWLLNDEYQ HVRVLYPKKT KHALPHLQDP QLVLLETKKG VIIQAEIFVN CKYGYDIQCE 

       250        260        270        280        290        300 
IAGEEGVISL PDVPAVRLCS NGRKGTEVLQ DWKKRFEAAY DVELQAFIDD GLKDEPASGP 

       310        320        330        340 
SAWDGYVAAV TADACVKAQE SGREESIELP KKPAFYQHSA ATPEQV 

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References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006627 Genomic DNA. Translation: BAD62969.1.
RefSeqYP_173930.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WKY6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING66692.ABC0427.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD62969; BAD62969; ABC0427.
GeneID3201776.
KEGGbcl:ABC0427.
PATRIC18920082. VBIBacCla58185_0446.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0673.
HOGENOMHOG000227439.
KOK00010.
OMAGDNYTTD.
OrthoDBEOG6GFGMS.

Enzyme and pathway databases

BioCycBCLA66692:GHMP-460-MONOMER.
UniPathwayUPA00076; UER00143.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01671. IolG.
InterProIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLG_BACSK
AccessionPrimary (citable) accession number: Q5WKY6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways