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Protein

Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

Gene

iolG

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.UniRule annotation

Catalytic activityi

Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation
1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH.UniRule annotation

Pathway:imyo-inositol degradation into acetyl-CoA

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (iolG)
  2. Inosose dehydratase (iolE)
  3. 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase (iolJ)
  7. Methylmalonate semialdehyde dehydrogenase [acylating] 1 (iolA1), Methylmalonate semialdehyde dehydrogenase [acylating] 2 (iolA2)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-460-MONOMER.
UniPathwayiUPA00076; UER00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation, EC:1.1.1.369UniRule annotation)
Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation
Short name:
MI 2-dehydrogenase/DCI 3-dehydrogenaseUniRule annotation
Gene namesi
Name:iolGUniRule annotation
Ordered Locus Names:ABC0427
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenasePRO_0000352555Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC0427.

Structurei

3D structure databases

ProteinModelPortaliQ5WKY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000227439.
KOiK00010.
OMAiATVYPND.
OrthoDBiEOG6GFGMS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WKY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRVGVIGT GAIGQDHIRR LECKLSGAKV TAVTDVNQDL ARKVANTYAK
60 70 80 90 100
QATVYANDRE LIAARDVDAV LVASWGPAHE ASVLAALEAG KRVFCEKPLA
110 120 130 140 150
TTADGCMRIV EAEMAHGKRL VQVGFMRRFD SGYLQLKQAL EQELVGEPLM
160 170 180 190 200
VRCIHRNVES AESYTTDMAI TDTLIHEIDV LHWLLNDEYQ HVRVLYPKKT
210 220 230 240 250
KHALPHLQDP QLVLLETKKG VIIQAEIFVN CKYGYDIQCE IAGEEGVISL
260 270 280 290 300
PDVPAVRLCS NGRKGTEVLQ DWKKRFEAAY DVELQAFIDD GLKDEPASGP
310 320 330 340
SAWDGYVAAV TADACVKAQE SGREESIELP KKPAFYQHSA ATPEQV
Length:346
Mass (Da):38,171
Last modified:November 23, 2004 - v1
Checksum:i3BBDA0E986095B37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD62969.1.
RefSeqiWP_011245288.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD62969; BAD62969; ABC0427.
KEGGibcl:ABC0427.
PATRICi18920082. VBIBacCla58185_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD62969.1.
RefSeqiWP_011245288.1. NC_006582.1.

3D structure databases

ProteinModelPortaliQ5WKY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi66692.ABC0427.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD62969; BAD62969; ABC0427.
KEGGibcl:ABC0427.
PATRICi18920082. VBIBacCla58185_0446.

Phylogenomic databases

eggNOGiCOG0673.
HOGENOMiHOG000227439.
KOiK00010.
OMAiATVYPND.
OrthoDBiEOG6GFGMS.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00143.
BioCyciBCLA66692:GHMP-460-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01671. IolG.
InterProiIPR023794. MI/DCI_dehydrogenase.
IPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
IPR004104. OxRdtase_C.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
PF02894. GFO_IDH_MocA_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiIOLG_BACSK
AccessioniPrimary (citable) accession number: Q5WKY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 23, 2004
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.