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Q5WKY6

- IOLG_BACSK

UniProt

Q5WKY6 - IOLG_BACSK

Protein

Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase

Gene

iolG

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.UniRule annotation

    Catalytic activityi

    Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.UniRule annotation
    1D-chiro-inositol + NAD+ = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. inositol 2-dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBCLA66692:GHMP-460-MONOMER.
    UniPathwayiUPA00076; UER00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation (EC:1.1.1.18UniRule annotation, EC:1.1.1.369UniRule annotation)
    Alternative name(s):
    Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenaseUniRule annotation
    Short name:
    MI 2-dehydrogenase/DCI 3-dehydrogenaseUniRule annotation
    Gene namesi
    Name:iolGUniRule annotation
    Ordered Locus Names:ABC0427
    OrganismiBacillus clausii (strain KSM-K16)
    Taxonomic identifieri66692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenasePRO_0000352555Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi66692.ABC0427.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WKY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Gfo/Idh/MocA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0673.
    HOGENOMiHOG000227439.
    KOiK00010.
    OMAiGDNYTTD.
    OrthoDBiEOG6GFGMS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01671. IolG.
    InterProiIPR023794. MI/DCI_dehydrogenase.
    IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    IPR004104. OxRdtase_C.
    [Graphical view]
    PfamiPF01408. GFO_IDH_MocA. 1 hit.
    PF02894. GFO_IDH_MocA_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5WKY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVRVGVIGT GAIGQDHIRR LECKLSGAKV TAVTDVNQDL ARKVANTYAK    50
    QATVYANDRE LIAARDVDAV LVASWGPAHE ASVLAALEAG KRVFCEKPLA 100
    TTADGCMRIV EAEMAHGKRL VQVGFMRRFD SGYLQLKQAL EQELVGEPLM 150
    VRCIHRNVES AESYTTDMAI TDTLIHEIDV LHWLLNDEYQ HVRVLYPKKT 200
    KHALPHLQDP QLVLLETKKG VIIQAEIFVN CKYGYDIQCE IAGEEGVISL 250
    PDVPAVRLCS NGRKGTEVLQ DWKKRFEAAY DVELQAFIDD GLKDEPASGP 300
    SAWDGYVAAV TADACVKAQE SGREESIELP KKPAFYQHSA ATPEQV 346
    Length:346
    Mass (Da):38,171
    Last modified:November 23, 2004 - v1
    Checksum:i3BBDA0E986095B37
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD62969.1.
    RefSeqiYP_173930.1. NC_006582.1.

    Genome annotation databases

    EnsemblBacteriaiBAD62969; BAD62969; ABC0427.
    GeneIDi3201776.
    KEGGibcl:ABC0427.
    PATRICi18920082. VBIBacCla58185_0446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD62969.1 .
    RefSeqi YP_173930.1. NC_006582.1.

    3D structure databases

    ProteinModelPortali Q5WKY6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66692.ABC0427.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD62969 ; BAD62969 ; ABC0427 .
    GeneIDi 3201776.
    KEGGi bcl:ABC0427.
    PATRICi 18920082. VBIBacCla58185_0446.

    Phylogenomic databases

    eggNOGi COG0673.
    HOGENOMi HOG000227439.
    KOi K00010.
    OMAi GDNYTTD.
    OrthoDBi EOG6GFGMS.

    Enzyme and pathway databases

    UniPathwayi UPA00076 ; UER00143 .
    BioCyci BCLA66692:GHMP-460-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01671. IolG.
    InterProi IPR023794. MI/DCI_dehydrogenase.
    IPR016040. NAD(P)-bd_dom.
    IPR000683. Oxidoreductase_N.
    IPR004104. OxRdtase_C.
    [Graphical view ]
    Pfami PF01408. GFO_IDH_MocA. 1 hit.
    PF02894. GFO_IDH_MocA_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
      Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KSM-K16.

    Entry informationi

    Entry nameiIOLG_BACSK
    AccessioniPrimary (citable) accession number: Q5WKY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3