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Q5WKM9 (AROD_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:ABC0536
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214

Subunit structure

Homodimer By similarity. HAMAP MF_00214

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2562563-dehydroquinate dehydratase HAMAP MF_00214
PRO_0000325518

Sites

Active site1441Proton acceptor By similarity
Active site1711Schiff-base intermediate with substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5WKM9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 1034640D691D53EA

FASTA25627,719
        10         20         30         40         50         60 
MGKPIQKTDG STPQRPLICA PLVGKTKAAL IEEIDAVAAK KPDLLEWRVD FYKHIGKTED 

        70         80         90        100        110        120 
VLETASLLKA HSKGIPILFT RRSIREGGEP ITVSEQEVTA LYEQVMKLGL VDVVDVELSC 

       130        140        150        160        170        180 
PEAEKERLRA IAKETETQWI LSYHDFQRTP SEADILAKLQ EAEANGADVG KVAVMPETMA 

       190        200        210        220        230        240 
DVLTLMQATQ KAASTLTIPV ITMAMGRLGT LSRMAGGACG SALTFAIANE SSAPGQMPID 

       250 
ELRSVLDVID RYVTGQ

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD63076.1.
RefSeqYP_174037.1. NC_006582.1.

3D structure databases

HSSPHSSP built from PDB template 1GQN based on UniProtKB P24670.
ProteinModelPortalQ5WKM9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WKM9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000048023; EBBACP00000046784; EBBACG00000048014.
GeneID3201723.
GenomeReviewsGene locus ABC0536 in contig AP006627_GR.
KEGGbcl:ABC0536.
NMPDRfig|66692.3.peg.537.
PATRIC18920318. VBIBacCla58185_0564.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0710.
GeneTreeEBGT00050000001972.
HOGENOMHBG732926.
OMAEFRMDLA.
ProtClustDBPRK02412.

Enzyme and pathway databases

BioCycBCLA66692:ABC0536-MONOMER.

Family and domain databases

HAMAPMF_00214. AroD.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK03785.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. AroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_BACSK
AccessionPrimary (citable) accession number: Q5WKM9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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