Reviewed, UniProtKB/Swiss-Prot Q5WKJ3 (XYLA_BACSK)

Names and origin

Protein names

Recommended name:
    Xylose isomerase
    EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	ABC0572

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Xylose isomerase HAMAP MF_00455		PRO_0000236955
Sites
	Active site	99	1	By similarity
	Active site	102	1	By similarity
	Metal binding	230	1	Magnesium 1 By similarity
	Metal binding	266	1	Magnesium 1 By similarity
	Metal binding	266	1	Magnesium 2 By similarity
	Metal binding	269	1	Magnesium 2 By similarity
	Metal binding	294	1	Magnesium 1 By similarity
	Metal binding	305	1	Magnesium 2 By similarity
	Metal binding	307	1	Magnesium 2 By similarity
	Metal binding	337	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WKJ3-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 0AED6DA32310780A	FASTA	439	49,421
	10 20 30 40 50 60 MSYFPAVNHI SYEGAKSDNP FAFKFYNPDE IVSGKTMAEH LRFSIAYWHT FTEALSDPFG 70 80 90 100 110 120 AGTAIRPWNA YTGMDLAKAR VEAAFEFFEK INVPYFCFHD VDIAPEGSSL KETYANLDVI 130 140 150 160 170 180 VAMIKDYMKD SNTKLLWNTA NNFTHPRFVG GAASSNEADV FAYSAAKVKK GLEIGKELGA 190 200 210 220 230 240 ENYVFWGGRE GYESLLNTDL KLEMDNLGRF FHMAVDYAKE IGFDGQFLIE PKPKEPTTHQ 250 260 270 280 290 300 YDFDVATGYA FLQHYGLQDS FKFNIEANHA TLAGHTFEHE LRYARIHHML GSVDANQGDP 310 320 330 340 350 360 LLGWDTDEFP TDLYSTTLAM YEILQNGGLG RGGLNFDAKV RRGSFEADDL FFAHIAGMDS 370 380 390 400 410 420 FAIGLKVAQQ LIDDRVLEQF VDSRYQSYKE GIGREIVLGN TDFHQLEAHA LSLGEIKTRS 430 GRVERIKAII NQYLLNAFA

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD63112.1.
RefSeq	YP_174073.1.
3D structure databases
SMR	Q5WKJ3. Positions 3-435.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WKJ3.
Genome annotation databases
GeneID	3203595.
GenomeReviews	Gene locus ABC0572 in contig AP006627_GR.
KEGG	bcl:ABC0572.
NMPDR	fig|66692.3.peg.573.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WKJ3.
OMA	QFLIEPK.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC0572-MON.
Family and domain databases
HAMAP	MF_00455. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. IPR018115. Xylose_isomerase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_BACSK

Accession

Primary (citable) accession number: Q5WKJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)