Q5WKD5 (UXUA_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	ABC0631

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Mannonate dehydratase HAMAP MF_00106		PRO_0000170662

Sequences

	Sequence		Length	Mass (Da)
	Q5WKD5 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 0CD7E5E203BF6B4A	FASTA	358	41,342
	10 20 30 40 50 60 MRMTFRWYGE NNDSVTLEQI KQIPGVEGLV WALHDKVAGE VWPLEDIMQV KEQADRYGFH 70 80 90 100 110 120 LDVVESINVH EDIKLGLPTR DAYIENYKES IRNVAKVGAK VICYNFMPVF DWTRTDLFKE 130 140 150 160 170 180 MEDGSTALFY EKAKVDNMDP RELVRQTTSN AAFTMPGWEP ERLAHIEKSL KAYENVTEDD 190 200 210 220 230 240 LWEHLQYFLE QVLPVAEEHG IQMAIHPDDP PWSVFGLPRI ITSEAAVERF LQLSNSPAHG 250 260 270 280 290 300 ITLCSGSLGA NPENDIPKII RRFHDRIPFA HIRNVKIYEN GDFIETSHRS QDGSVNIADV 310 320 330 340 350 VKAYHENGFT GYVRPDHGRH IWNEKCRPGY GLYDRALGIM HLWGLWDAYE LEAKRRQS

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD63170.1.
RefSeq	YP_174131.1. NC_006582.1.
3D structure databases
ProteinModelPortal	Q5WKD5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WKD5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000047967; EBBACP00000046728; EBBACG00000047958.
GeneID	3203586.
GenomeReviews	Gene locus ABC0631 in contig AP006627_GR.
KEGG	bcl:ABC0631.
NMPDR	fig|66692.3.peg.730.
PATRIC	18920514. VBIBacCla58185_0662.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
GeneTree	EBGT00050000001836.
HOGENOM	HBG585927.
OMA	GIVWALH.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC0631-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BACSK

Accession

Primary (citable) accession number: Q5WKD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program