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Protein

Arsenate reductase

Gene

arsC

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].UniRule annotation

Catalytic activityi

Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10NucleophileUniRule annotation1
Active sitei82NucleophileUniRule annotation1
Active sitei89NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-893-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductaseUniRule annotation (EC:1.20.4.4UniRule annotation)
Gene namesi
Name:arsCUniRule annotation
Ordered Locus Names:ABC0837
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625161 – 139Arsenate reductaseAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ5WJS9

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC0837

Structurei

3D structure databases

ProteinModelPortaliQ5WJS9
SMRiQ5WJS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108UXE Bacteria
COG0394 LUCA
HOGENOMiHOG000273093
KOiK03741
OMAiSWHKSKA
OrthoDBiPOG091H07DS

Family and domain databases

HAMAPiMF_01624 Arsenate_reduct, 1 hit
InterProiView protein in InterPro
IPR014064 Arsenate_reductase_ArsC
IPR023485 Ptyr_pPase
IPR036196 Ptyr_pPase_sf
PfamiView protein in Pfam
PF01451 LMWPc, 1 hit
SMARTiView protein in SMART
SM00226 LMWPc, 1 hit
SUPFAMiSSF52788 SSF52788, 1 hit
TIGRFAMsiTIGR02691 arsC_pI258_fam, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WJS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKIIYFLC TGNSCRSQMA EGFGKHYLSD EWEVYSAGME AHGLNPNAVK
60 70 80 90 100
AMNEVGIDIS DQTSDLIHID LLNNADFVVT LCGDAADKCP LTPAHVKREH
110 120 130
WGFDDPAKAE GTKEERWMVF QRVRDEIGAR IKKFAETGE
Length:139
Mass (Da):15,567
Last modified:November 23, 2004 - v1
Checksum:i1CEED8D2B9BE64F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD63376.1
RefSeqiWP_011245692.1, NC_006582.1

Genome annotation databases

EnsemblBacteriaiBAD63376; BAD63376; ABC0837
GeneIDi34043853
KEGGibcl:ABC0837

Similar proteinsi

Entry informationi

Entry nameiARSC_BACSK
AccessioniPrimary (citable) accession number: Q5WJS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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