Reviewed, UniProtKB/Swiss-Prot Q5WJP5 (GCP_BACSK)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	ABC0871

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303266
Sites
	Metal binding	112	1	Zinc Potential
	Metal binding	116	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5WJP5-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 46CBB2B42DDF5833	FASTA	335	35,422
	10 20 30 40 50 60 MTTILAIETS CDETAAAVIE NGDTIRSNVV ATQMESHARF GGVVPEIASR HHVEVVTAVV 70 80 90 100 110 120 EEALEKAKVT YQDLTAVAVT EGPGLVGALL VGIHAAKAIA FAHGLPLIGV HHIAGHIYAN 130 140 150 160 170 180 QLVAKLQFPL LALVVSGGHT ELIYMEKDGQ FQVIGQTRDD AVGEAYDKVA RALALPYPGG 190 200 210 220 230 240 PNVEQLADTA EATLDLPRSW LEKDSYDFSF SGLKSAVLNR LNNDKQRGIV TDRAALAKGF 250 260 270 280 290 300 QESVVDVLVA KTVRAQAQFN VKQVVLAGGV AANKGLRKAL TEAFANKDVT LLVPPLSLCT 310 320 330 DNAAMIGACA HSMWLRGIAG NMAMNARPGL PLSSF

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD63410.1.
RefSeq	YP_174371.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WJP5.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	3202191.
GenomeReviews	Gene locus ABC0871 in contig AP006627_GR.
KEGG	bcl:ABC0871.
NMPDR	fig|66692.3.peg.228.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WJP5.
OMA	CKRALKQ.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC0871-MON.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BACSK

Accession

Primary (citable) accession number: Q5WJP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)