Q5WJ84 (PUR5_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	ABC1032

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741_B
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00741_B.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741_B		PRO_0000258330

Sequences

	Sequence		Length	Mass (Da)
	Q5WJ84 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 7BEA7FB93923C04B	FASTA	345	36,233
	10 20 30 40 50 60 MSNAYKEAGV DIEAGYEAVN RMKRHVERTA RKGVLGGLGG FGGNFDLSTL GLKEPVLVSG 70 80 90 100 110 120 TDGVGTKLMI AFMANKHDTI GQDAVAMCVN DIVVQGAEPL YFLDYLACGK AVPEKIEAIV 130 140 150 160 170 180 KGVADGCEIA GCALIGGETA EMPGMYEEDE YDLAGFSVGA VEKKDLLTGE HIQAGDVLIG 190 200 210 220 230 240 LPSSGLHSNG FSLVRKVLLQ DAGLTLQTEC ATLGKTLGEE LLTPTKIYVK PLLACLKQGL 250 260 270 280 290 300 LAGAAHITGG GFYENIPRML PKGVGIHIDY GSWPIPPIFS LIQEKGGLSE QDLFHTFNMG 310 320 330 340 IGMVLAVPED KHQQALATLE ANGEDAYIIG RVTPTEGTVI GGIGA

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD63571.1.
RefSeq	YP_174532.1. NC_006582.1.
3D structure databases
HSSP	HSSP built from PDB template 1CLI based on UniProtKB P08178.
ProteinModelPortal	Q5WJ84.
SMR	Q5WJ84. Positions 13-337.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WJ84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000047876; EBBACP00000046637; EBBACG00000047867.
GeneID	3202814.
GenomeReviews	Gene locus ABC1032 in contig AP006627_GR.
KEGG	bcl:ABC1032.
NMPDR	fig|66692.3.peg.492.
PATRIC	18921430. VBIBacCla58185_1103.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
GeneTree	EBGT00050000002660.
HOGENOM	HBG531222.
OMA	GIDMIAM.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC1032-MONOMER.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
KO	K01933.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. PurM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_BACSK

Accession

Primary (citable) accession number: Q5WJ84

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program