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Q5WIU9

- HISX1_BACSK

UniProt

Q5WIU9 - HISX1_BACSK

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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211NADUniRule annotation
Binding sitei182 – 1821NADUniRule annotation
Binding sitei205 – 2051NADUniRule annotation
Binding sitei228 – 2281SubstrateUniRule annotation
Metal bindingi250 – 2501ZincUniRule annotation
Binding sitei250 – 2501SubstrateUniRule annotation
Metal bindingi253 – 2531ZincUniRule annotation
Binding sitei253 – 2531SubstrateUniRule annotation
Active sitei318 – 3181Proton acceptorUniRule annotation
Active sitei319 – 3191Proton acceptorUniRule annotation
Binding sitei319 – 3191SubstrateUniRule annotation
Metal bindingi352 – 3521ZincUniRule annotation
Binding sitei352 – 3521SubstrateUniRule annotation
Binding sitei406 – 4061SubstrateUniRule annotation
Metal bindingi411 – 4111ZincUniRule annotation
Binding sitei411 – 4111SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-1214-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1UniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDH 1UniRule annotation
Gene namesi
Name:hisD1UniRule annotation
Ordered Locus Names:ABC1168
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenase 1PRO_0000135724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC1168.

Structurei

3D structure databases

ProteinModelPortaliQ5WIU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiVITCAPP.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WIU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQYIKQGKS ESELKDSHGK VEQTVASLIA RIEKEGETAV RELSRQFDNW
60 70 80 90 100
DPEQFRLSAE EIEKIVRSVP DQVKADICFA QEQIRHFAEQ QRASIQDIEV
110 120 130 140 150
ETRPGVFLGH KNIPVNSVGC YIPGGRYPMV ASSHMSILTA KVAGVKRVIG
160 170 180 190 200
CTPPINGEIP AATVTAMHFA GADEIYILGG VQAMTAMAVG TETIEAVDML
210 220 230 240 250
VGPGNAFVAE AKRQLFGRVG IDLFAGPTEV LIIADDTADG EMVATDLLGQ
260 270 280 290 300
AEHGPTSPAA LITTSKKLAE ETVAEIERQL QTLPTADVAK VAWEEHGMII
310 320 330 340 350
LVDDLAEAVV EADKLAYEHV QVLTENPNYF LDHMTNYGAL FLGPETNVAY
360 370 380 390 400
GDKVIGTNHT LPTKKAAKYT GGLWVGKFLK NCTYQRCTPE ASAEIGRIAE
410 420
RLCELEGFIG HKAQASLRVK RYGK
Length:424
Mass (Da):46,122
Last modified:November 23, 2004 - v1
Checksum:i6131743AA063022E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD63706.1.
RefSeqiYP_174667.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD63706; BAD63706; ABC1168.
GeneIDi3201041.
KEGGibcl:ABC1168.
PATRICi18921728. VBIBacCla58185_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD63706.1 .
RefSeqi YP_174667.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WIU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC1168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD63706 ; BAD63706 ; ABC1168 .
GeneIDi 3201041.
KEGGi bcl:ABC1168.
PATRICi 18921728. VBIBacCla58185_1252.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K15509.
OMAi VITCAPP.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BCLA66692:GHMP-1214-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiHISX1_BACSK
AccessioniPrimary (citable) accession number: Q5WIU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3