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Q5WIU9

- HISX1_BACSK

UniProt

Q5WIU9 - HISX1_BACSK

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Protein
Histidinol dehydrogenase 1
Gene
hisD1, ABC1168
Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211NAD By similarity
Binding sitei182 – 1821NAD By similarity
Binding sitei205 – 2051NAD By similarity
Binding sitei228 – 2281Substrate By similarity
Metal bindingi250 – 2501Zinc By similarity
Binding sitei250 – 2501Substrate By similarity
Metal bindingi253 – 2531Zinc By similarity
Binding sitei253 – 2531Substrate By similarity
Active sitei318 – 3181Proton acceptor By similarity
Active sitei319 – 3191Proton acceptor By similarity
Binding sitei319 – 3191Substrate By similarity
Metal bindingi352 – 3521Zinc By similarity
Binding sitei352 – 3521Substrate By similarity
Binding sitei406 – 4061Substrate By similarity
Metal bindingi411 – 4111Zinc By similarity
Binding sitei411 – 4111Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-1214-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1 (EC:1.1.1.23)
Short name:
HDH 1
Gene namesi
Name:hisD1
Ordered Locus Names:ABC1168
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenase 1UniRule annotation
PRO_0000135724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC1168.

Structurei

3D structure databases

ProteinModelPortaliQ5WIU9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiVITCAPP.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WIU9-1 [UniParc]FASTAAdd to Basket

« Hide

MAQYIKQGKS ESELKDSHGK VEQTVASLIA RIEKEGETAV RELSRQFDNW    50
DPEQFRLSAE EIEKIVRSVP DQVKADICFA QEQIRHFAEQ QRASIQDIEV 100
ETRPGVFLGH KNIPVNSVGC YIPGGRYPMV ASSHMSILTA KVAGVKRVIG 150
CTPPINGEIP AATVTAMHFA GADEIYILGG VQAMTAMAVG TETIEAVDML 200
VGPGNAFVAE AKRQLFGRVG IDLFAGPTEV LIIADDTADG EMVATDLLGQ 250
AEHGPTSPAA LITTSKKLAE ETVAEIERQL QTLPTADVAK VAWEEHGMII 300
LVDDLAEAVV EADKLAYEHV QVLTENPNYF LDHMTNYGAL FLGPETNVAY 350
GDKVIGTNHT LPTKKAAKYT GGLWVGKFLK NCTYQRCTPE ASAEIGRIAE 400
RLCELEGFIG HKAQASLRVK RYGK 424
Length:424
Mass (Da):46,122
Last modified:November 23, 2004 - v1
Checksum:i6131743AA063022E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD63706.1.
RefSeqiYP_174667.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD63706; BAD63706; ABC1168.
GeneIDi3201041.
KEGGibcl:ABC1168.
PATRICi18921728. VBIBacCla58185_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD63706.1 .
RefSeqi YP_174667.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WIU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC1168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD63706 ; BAD63706 ; ABC1168 .
GeneIDi 3201041.
KEGGi bcl:ABC1168.
PATRICi 18921728. VBIBacCla58185_1252.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K15509.
OMAi VITCAPP.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BCLA66692:GHMP-1214-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiHISX1_BACSK
AccessioniPrimary (citable) accession number: Q5WIU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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