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Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211NADUniRule annotation
Binding sitei182 – 1821NADUniRule annotation
Binding sitei205 – 2051NADUniRule annotation
Binding sitei228 – 2281SubstrateUniRule annotation
Metal bindingi250 – 2501ZincUniRule annotation
Binding sitei250 – 2501SubstrateUniRule annotation
Metal bindingi253 – 2531ZincUniRule annotation
Binding sitei253 – 2531SubstrateUniRule annotation
Active sitei318 – 3181Proton acceptorUniRule annotation
Active sitei319 – 3191Proton acceptorUniRule annotation
Binding sitei319 – 3191SubstrateUniRule annotation
Metal bindingi352 – 3521ZincUniRule annotation
Binding sitei352 – 3521SubstrateUniRule annotation
Binding sitei406 – 4061SubstrateUniRule annotation
Metal bindingi411 – 4111ZincUniRule annotation
Binding sitei411 – 4111SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-1214-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 1UniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDH 1UniRule annotation
Gene namesi
Name:hisD1UniRule annotation
Ordered Locus Names:ABC1168
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenase 1PRO_0000135724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC1168.

Structurei

3D structure databases

ProteinModelPortaliQ5WIU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiVPGGKYP.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WIU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQYIKQGKS ESELKDSHGK VEQTVASLIA RIEKEGETAV RELSRQFDNW
60 70 80 90 100
DPEQFRLSAE EIEKIVRSVP DQVKADICFA QEQIRHFAEQ QRASIQDIEV
110 120 130 140 150
ETRPGVFLGH KNIPVNSVGC YIPGGRYPMV ASSHMSILTA KVAGVKRVIG
160 170 180 190 200
CTPPINGEIP AATVTAMHFA GADEIYILGG VQAMTAMAVG TETIEAVDML
210 220 230 240 250
VGPGNAFVAE AKRQLFGRVG IDLFAGPTEV LIIADDTADG EMVATDLLGQ
260 270 280 290 300
AEHGPTSPAA LITTSKKLAE ETVAEIERQL QTLPTADVAK VAWEEHGMII
310 320 330 340 350
LVDDLAEAVV EADKLAYEHV QVLTENPNYF LDHMTNYGAL FLGPETNVAY
360 370 380 390 400
GDKVIGTNHT LPTKKAAKYT GGLWVGKFLK NCTYQRCTPE ASAEIGRIAE
410 420
RLCELEGFIG HKAQASLRVK RYGK
Length:424
Mass (Da):46,122
Last modified:November 22, 2004 - v1
Checksum:i6131743AA063022E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD63706.1.
RefSeqiYP_174667.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD63706; BAD63706; ABC1168.
KEGGibcl:ABC1168.
PATRICi18921728. VBIBacCla58185_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD63706.1.
RefSeqiYP_174667.1. NC_006582.1.

3D structure databases

ProteinModelPortaliQ5WIU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi66692.ABC1168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD63706; BAD63706; ABC1168.
KEGGibcl:ABC1168.
PATRICi18921728. VBIBacCla58185_1252.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK15509.
OMAiVPGGKYP.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciBCLA66692:GHMP-1214-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiHISX1_BACSK
AccessioniPrimary (citable) accession number: Q5WIU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2006
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.