Reviewed, UniProtKB/Swiss-Prot Q5WIU9 (HISX1_BACSK)

Names and origin

Protein names

Recommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23

Gene names

Name:	hisD1
Ordered Locus Names:	ABC1168

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	424 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Sequence similarities	Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 424	424	Histidinol dehydrogenase 1		PRO_0000135724
Sites
	Active site	318	1	Proton acceptor By similarity
	Active site	319	1	Proton acceptor By similarity
	Metal binding	250	1	Zinc By similarity
	Metal binding	253	1	Zinc By similarity
	Metal binding	352	1	Zinc By similarity
	Metal binding	411	1	Zinc By similarity
	Binding site	121	1	NAD By similarity
	Binding site	182	1	NAD By similarity
	Binding site	205	1	NAD By similarity
	Binding site	228	1	Substrate By similarity
	Binding site	250	1	Substrate By similarity
	Binding site	253	1	Substrate By similarity
	Binding site	319	1	Substrate By similarity
	Binding site	352	1	Substrate By similarity
	Binding site	406	1	Substrate By similarity
	Binding site	411	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WIU9-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 6131743AA063022E	FASTA	424	46,122
	10 20 30 40 50 60 MAQYIKQGKS ESELKDSHGK VEQTVASLIA RIEKEGETAV RELSRQFDNW DPEQFRLSAE 70 80 90 100 110 120 EIEKIVRSVP DQVKADICFA QEQIRHFAEQ QRASIQDIEV ETRPGVFLGH KNIPVNSVGC 130 140 150 160 170 180 YIPGGRYPMV ASSHMSILTA KVAGVKRVIG CTPPINGEIP AATVTAMHFA GADEIYILGG 190 200 210 220 230 240 VQAMTAMAVG TETIEAVDML VGPGNAFVAE AKRQLFGRVG IDLFAGPTEV LIIADDTADG 250 260 270 280 290 300 EMVATDLLGQ AEHGPTSPAA LITTSKKLAE ETVAEIERQL QTLPTADVAK VAWEEHGMII 310 320 330 340 350 360 LVDDLAEAVV EADKLAYEHV QVLTENPNYF LDHMTNYGAL FLGPETNVAY GDKVIGTNHT 370 380 390 400 410 420 LPTKKAAKYT GGLWVGKFLK NCTYQRCTPE ASAEIGRIAE RLCELEGFIG HKAQASLRVK RYGK

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD63706.1.
RefSeq	YP_174667.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3201041.
GenomeReviews	Gene locus ABC1168 in contig AP006627_GR.
KEGG	bcl:ABC1168.
NMPDR	fig|66692.3.peg.742.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WIU9.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC1168-MON.
Family and domain databases
HAMAP	MF_01024. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX1_BACSK

Accession

Primary (citable) accession number: Q5WIU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	November 23, 2004
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)