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Q5WIU9

- HISX1_BACSK

UniProt

Q5WIU9 - HISX1_BACSK

Protein

Histidinol dehydrogenase 1

Gene

hisD1

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211NADUniRule annotation
    Binding sitei182 – 1821NADUniRule annotation
    Binding sitei205 – 2051NADUniRule annotation
    Binding sitei228 – 2281SubstrateUniRule annotation
    Metal bindingi250 – 2501ZincUniRule annotation
    Binding sitei250 – 2501SubstrateUniRule annotation
    Metal bindingi253 – 2531ZincUniRule annotation
    Binding sitei253 – 2531SubstrateUniRule annotation
    Active sitei318 – 3181Proton acceptorUniRule annotation
    Active sitei319 – 3191Proton acceptorUniRule annotation
    Binding sitei319 – 3191SubstrateUniRule annotation
    Metal bindingi352 – 3521ZincUniRule annotation
    Binding sitei352 – 3521SubstrateUniRule annotation
    Binding sitei406 – 4061SubstrateUniRule annotation
    Metal bindingi411 – 4111ZincUniRule annotation
    Binding sitei411 – 4111SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciBCLA66692:GHMP-1214-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 1UniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDH 1UniRule annotation
    Gene namesi
    Name:hisD1UniRule annotation
    Ordered Locus Names:ABC1168
    OrganismiBacillus clausii (strain KSM-K16)
    Taxonomic identifieri66692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Histidinol dehydrogenase 1PRO_0000135724Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi66692.ABC1168.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WIU9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK15509.
    OMAiVITCAPP.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5WIU9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQYIKQGKS ESELKDSHGK VEQTVASLIA RIEKEGETAV RELSRQFDNW    50
    DPEQFRLSAE EIEKIVRSVP DQVKADICFA QEQIRHFAEQ QRASIQDIEV 100
    ETRPGVFLGH KNIPVNSVGC YIPGGRYPMV ASSHMSILTA KVAGVKRVIG 150
    CTPPINGEIP AATVTAMHFA GADEIYILGG VQAMTAMAVG TETIEAVDML 200
    VGPGNAFVAE AKRQLFGRVG IDLFAGPTEV LIIADDTADG EMVATDLLGQ 250
    AEHGPTSPAA LITTSKKLAE ETVAEIERQL QTLPTADVAK VAWEEHGMII 300
    LVDDLAEAVV EADKLAYEHV QVLTENPNYF LDHMTNYGAL FLGPETNVAY 350
    GDKVIGTNHT LPTKKAAKYT GGLWVGKFLK NCTYQRCTPE ASAEIGRIAE 400
    RLCELEGFIG HKAQASLRVK RYGK 424
    Length:424
    Mass (Da):46,122
    Last modified:November 23, 2004 - v1
    Checksum:i6131743AA063022E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD63706.1.
    RefSeqiYP_174667.1. NC_006582.1.

    Genome annotation databases

    EnsemblBacteriaiBAD63706; BAD63706; ABC1168.
    GeneIDi3201041.
    KEGGibcl:ABC1168.
    PATRICi18921728. VBIBacCla58185_1252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD63706.1 .
    RefSeqi YP_174667.1. NC_006582.1.

    3D structure databases

    ProteinModelPortali Q5WIU9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66692.ABC1168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD63706 ; BAD63706 ; ABC1168 .
    GeneIDi 3201041.
    KEGGi bcl:ABC1168.
    PATRICi 18921728. VBIBacCla58185_1252.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K15509.
    OMAi VITCAPP.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci BCLA66692:GHMP-1214-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
      Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KSM-K16.

    Entry informationi

    Entry nameiHISX1_BACSK
    AccessioniPrimary (citable) accession number: Q5WIU9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3