Reviewed,
UniProtKB/Swiss-Prot Q5WIU9 (HISX1_BACSK)
Last modified
November 25, 2008.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Histidinol dehydrogenase 1 Short name=HDH 1 EC=1.1.1.23 | ||||
| Gene names |
| ||||
| Organism | Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 66692 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 424 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. |
| Catalytic activity | L-histidinol + 2 NAD(+) = L-histidine + 2 NADH. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the histidinol dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Histidine biosynthesis |
| Ligand | Metal-binding NAD Zinc |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activityInferred from electronic annotation. Source: HAMAP zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 424 | 424 | Histidinol dehydrogenase 1 | PRO_0000135724 | |||||
Sites | |||||||||
| Active site | 318 | 1 | Proton acceptor By similarity | ||||||
| Active site | 319 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 250 | 1 | Zinc By similarity | ||||||
| Metal binding | 253 | 1 | Zinc By similarity | ||||||
| Metal binding | 352 | 1 | Zinc By similarity | ||||||
| Metal binding | 411 | 1 | Zinc By similarity | ||||||
| Binding site | 121 | 1 | NAD By similarity | ||||||
| Binding site | 182 | 1 | NAD By similarity | ||||||
| Binding site | 205 | 1 | NAD By similarity | ||||||
| Binding site | 228 | 1 | Substrate By similarity | ||||||
| Binding site | 250 | 1 | Substrate By similarity | ||||||
| Binding site | 253 | 1 | Substrate By similarity | ||||||
| Binding site | 319 | 1 | Substrate By similarity | ||||||
| Binding site | 352 | 1 | Substrate By similarity | ||||||
| Binding site | 406 | 1 | Substrate By similarity | ||||||
| Binding site | 411 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| AP006627 Genomic DNA. Translation: BAD63706.1. | |
| RefSeq | YP_174667.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3201041. |
| GenomeReviews | Gene locus ABC1168 in contig AP006627_GR. |
| KEGG | bcl:ABC1168. |
| NMPDR | fig|66692.3.peg.742. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q5WIU9. |
Enzyme and pathway databases | |
| BioCyc | BCLA66692:ABC1168-MON. |
Family and domain databases | |
| HAMAP | MF_01024. [Tree] |
| InterPro | IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view] |
| PANTHER | PTHR21256:SF2. Hstdl_DH_prok. 1 hit. |
| Pfam | PF00815. Histidinol_dh. 1 hit. [Graphical view] |
| PRINTS | PR00083. HOLDHDRGNASE. |
| ProDom | PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00069. hisD. 1 hit. |
| PROSITE | PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HISX1_BACSK | ||||||||
| Accession | Primary (citable) accession number: Q5WIU9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


