Q5WHY3 (ARLY1_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase 1
Short name=ASAL 1
EC=4.3.2.1

Alternative name(s):
Arginosuccinase 1

Gene names

Name:	argH1
Ordered Locus Names:	ABC1487

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 498	498	Argininosuccinate lyase 1 HAMAP MF_00006		PRO_0000240712

Sequences

	Sequence		Length	Mass (Da)
	Q5WHY3-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 327B7C4574427E31	FASTA	498	55,866
	10 20 30 40 50 60 MVGRLKESPS QEMIDLLFKP SIRSDLKHHY SYLLKINSVH LFMLKSEGII SDEAASKIHS 70 80 90 100 110 120 VLTHLQVTGK EALSINPALE DLYFNVEAYI IEQTGPEIGG QMHTGRSRND ILATVTRMRI 130 140 150 160 170 180 REEMLEIYEL VCTLRRTLID LATEHTSTLM TGYTHLQPAE PITFAHYLSA LLHGFERDFT 190 200 210 220 230 240 RLYNCYAHIN KSPLGSCALA STTFSINRKF TMELLGFADL LENSLDGIAS RDYALEALSA 250 260 270 280 290 300 LSIFSNSLSR FAQDLYTWCS YEFGYLEVGH SVAVISSIMP QKKNPVTLEH IKAKAGHIQG 310 320 330 340 350 360 ALVSSLSVLK NTLYSHSRDT SMESMKYTWE AINETKAAIR LMIKTLQTLT VHKDNMAATT 370 380 390 400 410 420 RQNFSTVTEL ANALVRHYHF SFRTAHHIVA EIVNETLNQG LGSDKIEAST VERAIKQVTA 430 440 450 460 470 480 KTVSVTKEFV EQALDPERNI SLRTVRGGSA PVEVARQLQQ LEQTLASDHQ KISDLKQALQ 490 SADQLYKHYA AELERGAQ

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD64022.1.
RefSeq	YP_174983.1.
3D structure databases
ProteinModelPortal	Q5WHY3.
SMR	Q5WHY3. Positions 16-468.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WHY3.
Genome annotation databases
EnsemblBacteria	EBBACT00000046121; EBBACP00000044882; EBBACG00000046112.
GeneID	3203346.
GenomeReviews	Gene locus ABC1487 in contig AP006627_GR.
KEGG	bcl:ABC1487.
NMPDR	fig|66692.3.peg.1861.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	RSRNDIG.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC1487-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY1_BACSK

Accession

Primary (citable) accession number: Q5WHY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 23, 2004
Last modified:	August 10, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)