ID   AROE_BACSK              Reviewed;         275 AA.
AC   Q5WHI2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   16-JUN-2009, entry version 36.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=ABC1638;
OS   Bacillus clausii (strain KSM-K16).
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=66692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA   Kawai S., Ito S., Horikoshi K.;
RT   "The complete genome sequence of the alkaliphilic Bacillus clausii
RT   KSM-K16.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AP006627; BAD64173.1; -; Genomic_DNA.
DR   RefSeq; YP_175134.1; -.
DR   GeneID; 3201724; -.
DR   GenomeReviews; AP006627_GR; ABC1638.
DR   KEGG; bcl:ABC1638; -.
DR   NMPDR; fig|66692.3.peg.1600; -.
DR   HOGENOM; Q5WHI2; -.
DR   OMA; Q5WHI2; IVSDIIY.
DR   BioCyc; BCLA66692:ABC1638-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    275       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000021264.
FT   NP_BIND     128    132       NADP (By similarity).
FT   ACT_SITE     66     66       Proton acceptor (Potential).
SQ   SEQUENCE   275 AA;  30045 MW;  BBC7F15F40DDC9FE CRC64;
     MTRQFGLIGH PLGHSKSPVM HEAAYKDMGL DAVYCAYDIS PQELGNAIRT MKAQGIDGFN
     VTIPHKVAII DYLDEIDEDA EAMGAVNTVV CQDGRWVGKN TDADGYIESL LPVVSDQSLT
     GRRVLVIGAG GAARAVIHAL GKQRATISVS NRTAEKAQEL AQLFSHLTIE AIPLNEAEST
     LGTYDVLINT TSVGMYPDTS KQPIALDRLK QATIVSDLIY NPYETALLQE AKQRGNRILN
     GIGMFVNQGA LSIEHWTGRK PNRKCMERVV RMHLT
//