Q5WHI2 (AROE_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	ABC1638

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021264
Regions
	Nucleotide binding	128 – 132	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5WHI2 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: BBC7F15F40DDC9FE	FASTA	275	30,045
	10 20 30 40 50 60 MTRQFGLIGH PLGHSKSPVM HEAAYKDMGL DAVYCAYDIS PQELGNAIRT MKAQGIDGFN 70 80 90 100 110 120 VTIPHKVAII DYLDEIDEDA EAMGAVNTVV CQDGRWVGKN TDADGYIESL LPVVSDQSLT 130 140 150 160 170 180 GRRVLVIGAG GAARAVIHAL GKQRATISVS NRTAEKAQEL AQLFSHLTIE AIPLNEAEST 190 200 210 220 230 240 LGTYDVLINT TSVGMYPDTS KQPIALDRLK QATIVSDLIY NPYETALLQE AKQRGNRILN 250 260 270 GIGMFVNQGA LSIEHWTGRK PNRKCMERVV RMHLT

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD64173.1.
RefSeq	YP_175134.1. NC_006582.1.
3D structure databases
HSSP	HSSP built from PDB template 1NVT based on UniProtKB Q58484.
ProteinModelPortal	Q5WHI2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WHI2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000049359; EBBACP00000048120; EBBACG00000049350.
GeneID	3201724.
GenomeReviews	Gene locus ABC1638 in contig AP006627_GR.
KEGG	bcl:ABC1638.
NMPDR	fig|66692.3.peg.1600.
PATRIC	18922748. VBIBacCla58185_1742.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000000826.
HOGENOM	HBG553408.
OMA	FEMWTGC.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC1638-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BACSK

Accession

Primary (citable) accession number: Q5WHI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program