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Q5WH44 (UPPP1_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 1

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene names
Name:uppP1
Ordered Locus Names:ABC1776
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006
PRO_0000151107

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5820Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane113 – 13321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane251 – 27121Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5WH44 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5E8DF896606E9EF4

FASTA27730,396
        10         20         30         40         50         60 
MSLLEAVILG LVQGITEFLP ISSSAHLILV QALFGMTFAG FSFEILLHLA SVLAVILYYR 

        70         80         90        100        110        120 
HDLIEIIRGF FAYFTKRTPQ NKAMFWFAIY LVVATGITGV AGILFEDYIS ETFKAPIFIA 

       130        140        150        160        170        180 
LALAVTGLFL IIIERFVRHG NRTEKEMTIW DSIIVGLGQC LALIPGLSRS GTTLIVGMFA 

       190        200        210        220        230        240 
GLTKETAVRF SFLLSIPVIL GSSVLAIDDL ISGDLLASTG LFELAASFVV TFIASWLGIV 

       250        260        270 
FFLNLVRKSK LVYFAVYCFI VAILVFIFQD ALGHADI 

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006627 Genomic DNA. Translation: BAD64311.1.
RefSeqYP_175272.1. NC_006582.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING66692.ABC1776.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD64311; BAD64311; ABC1776.
GeneID3201173.
KEGGbcl:ABC1776.
PATRIC18923052. VBIBacCla58185_1889.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMATEKEMTI.
OrthoDBEOG6QP13M.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycBCLA66692:GHMP-1844-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP1_BACSK
AccessionPrimary (citable) accession number: Q5WH44
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families