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Q5WH44

- UPPP1_BACSK

UniProt

Q5WH44 - UPPP1_BACSK

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Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-1844-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance protein 1UniRule annotation
Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
Gene namesi
Name:uppP1UniRule annotation
Ordered Locus Names:ABC1776
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei39 – 5820HelicalUniRule annotationAdd
BLAST
Transmembranei85 – 10521HelicalUniRule annotationAdd
BLAST
Transmembranei113 – 13321HelicalUniRule annotationAdd
BLAST
Transmembranei147 – 16721HelicalUniRule annotationAdd
BLAST
Transmembranei191 – 21121HelicalUniRule annotationAdd
BLAST
Transmembranei226 – 24621HelicalUniRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Undecaprenyl-diphosphatase 1PRO_0000151107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC1776.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiNITIIAW.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WH44-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLLEAVILG LVQGITEFLP ISSSAHLILV QALFGMTFAG FSFEILLHLA
60 70 80 90 100
SVLAVILYYR HDLIEIIRGF FAYFTKRTPQ NKAMFWFAIY LVVATGITGV
110 120 130 140 150
AGILFEDYIS ETFKAPIFIA LALAVTGLFL IIIERFVRHG NRTEKEMTIW
160 170 180 190 200
DSIIVGLGQC LALIPGLSRS GTTLIVGMFA GLTKETAVRF SFLLSIPVIL
210 220 230 240 250
GSSVLAIDDL ISGDLLASTG LFELAASFVV TFIASWLGIV FFLNLVRKSK
260 270
LVYFAVYCFI VAILVFIFQD ALGHADI
Length:277
Mass (Da):30,396
Last modified:November 23, 2004 - v1
Checksum:i5E8DF896606E9EF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD64311.1.
RefSeqiYP_175272.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD64311; BAD64311; ABC1776.
GeneIDi3201173.
KEGGibcl:ABC1776.
PATRICi18923052. VBIBacCla58185_1889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD64311.1 .
RefSeqi YP_175272.1. NC_006582.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC1776.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD64311 ; BAD64311 ; ABC1776 .
GeneIDi 3201173.
KEGGi bcl:ABC1776.
PATRICi 18923052. VBIBacCla58185_1889.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi NITIIAW.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-1844-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiUPPP1_BACSK
AccessioniPrimary (citable) accession number: Q5WH44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3