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Q5WH44

- UPPP1_BACSK

UniProt

Q5WH44 - UPPP1_BACSK

Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBCLA66692:GHMP-1844-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 1UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
    Gene namesi
    Name:uppP1UniRule annotation
    Ordered Locus Names:ABC1776
    OrganismiBacillus clausii (strain KSM-K16)
    Taxonomic identifieri66692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001168: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 277277Undecaprenyl-diphosphatase 1PRO_0000151107Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi66692.ABC1776.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5820HelicalUniRule annotationAdd
    BLAST
    Transmembranei85 – 10521HelicalUniRule annotationAdd
    BLAST
    Transmembranei113 – 13321HelicalUniRule annotationAdd
    BLAST
    Transmembranei147 – 16721HelicalUniRule annotationAdd
    BLAST
    Transmembranei191 – 21121HelicalUniRule annotationAdd
    BLAST
    Transmembranei226 – 24621HelicalUniRule annotationAdd
    BLAST
    Transmembranei251 – 27121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiNITIIAW.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5WH44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLEAVILG LVQGITEFLP ISSSAHLILV QALFGMTFAG FSFEILLHLA    50
    SVLAVILYYR HDLIEIIRGF FAYFTKRTPQ NKAMFWFAIY LVVATGITGV 100
    AGILFEDYIS ETFKAPIFIA LALAVTGLFL IIIERFVRHG NRTEKEMTIW 150
    DSIIVGLGQC LALIPGLSRS GTTLIVGMFA GLTKETAVRF SFLLSIPVIL 200
    GSSVLAIDDL ISGDLLASTG LFELAASFVV TFIASWLGIV FFLNLVRKSK 250
    LVYFAVYCFI VAILVFIFQD ALGHADI 277
    Length:277
    Mass (Da):30,396
    Last modified:November 23, 2004 - v1
    Checksum:i5E8DF896606E9EF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD64311.1.
    RefSeqiYP_175272.1. NC_006582.1.

    Genome annotation databases

    EnsemblBacteriaiBAD64311; BAD64311; ABC1776.
    GeneIDi3201173.
    KEGGibcl:ABC1776.
    PATRICi18923052. VBIBacCla58185_1889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD64311.1 .
    RefSeqi YP_175272.1. NC_006582.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66692.ABC1776.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD64311 ; BAD64311 ; ABC1776 .
    GeneIDi 3201173.
    KEGGi bcl:ABC1776.
    PATRICi 18923052. VBIBacCla58185_1889.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi NITIIAW.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BCLA66692:GHMP-1844-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
      Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KSM-K16.

    Entry informationi

    Entry nameiUPPP1_BACSK
    AccessioniPrimary (citable) accession number: Q5WH44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3