Q5WH44 (UPPP1_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Ordered Locus Names:	ABC1776

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus clausii

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 277	277	Undecaprenyl-diphosphatase 1 HAMAP-Rule MF_01006		PRO_0000151107
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 58	20	Helical; Potential
	Transmembrane	85 – 105	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	226 – 246	21	Helical; Potential
	Transmembrane	251 – 271	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5WH44 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5E8DF896606E9EF4	FASTA	277	30,396
	10 20 30 40 50 60 MSLLEAVILG LVQGITEFLP ISSSAHLILV QALFGMTFAG FSFEILLHLA SVLAVILYYR 70 80 90 100 110 120 HDLIEIIRGF FAYFTKRTPQ NKAMFWFAIY LVVATGITGV AGILFEDYIS ETFKAPIFIA 130 140 150 160 170 180 LALAVTGLFL IIIERFVRHG NRTEKEMTIW DSIIVGLGQC LALIPGLSRS GTTLIVGMFA 190 200 210 220 230 240 GLTKETAVRF SFLLSIPVIL GSSVLAIDDL ISGDLLASTG LFELAASFVV TFIASWLGIV 250 260 270 FFLNLVRKSK LVYFAVYCFI VAILVFIFQD ALGHADI

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD64311.1.
RefSeq	YP_175272.1. NC_006582.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	66692.ABC1776.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD64311; BAD64311; ABC1776.
GeneID	3201173.
KEGG	bcl:ABC1776.
PATRIC	18923052. VBIBacCla58185_1889.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	TISAMMF.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	BCLA66692:GHMP-1769-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_BACSK

Accession

Primary (citable) accession number: Q5WH44

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program