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Q5WGS8 (AROC_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chorismate synthase
EC=4.2.3.5
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase
Gene names
Name:aroC
Ordered Locus Names:ABC1892
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300

Cofactor

Reduced flavin By similarity. HAMAP MF_00300

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300

Subunit structure

Homotetramer By similarity. HAMAP MF_00300

Sequence similarities

Belongs to the chorismate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchorismate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Chorismate synthase HAMAP MF_00300
PRO_0000140552

Sequences

Sequence LengthMass (Da)Tools
Q5WGS8 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 84462E7826997D0E

FASTA39042,378
        10         20         30         40         50         60 
MRFLTAGESH GPQLTAIIEG VPAQLPLLAE DIDRELARRQ GGYGRGRRMQ IEKDRVQIVS 

        70         80         90        100        110        120 
GVRHGMTTGA PITFVVENKD WKNWTKIMGA EPISEEEAEK MRRKLTRPRP GHADLNGAIK 

       130        140        150        160        170        180 
YGHRDMRNVL ERSSARETTV RVACGALAKV ILKACGIEVA GHVREIGGIR AEETNYATIQ 

       190        200        210        220        230        240 
ELQKRSEESP VRCLDEDASK KMMAAIDKAK QDGDSIGGIV EVVVAGVPIG LGSHVHYDRK 

       250        260        270        280        290        300 
LDGKIAGAVM SINAFKGVEI GIGFEAARLP GSQVHDEITW SEEEGYKRKT NRLGGFEGGM 

       310        320        330        340        350        360 
TNGMPIVVKG VMKPIPTLYK PLQSVDIDSK EPFAAGVERS DSCAVPAASV VCENVVAWEV 

       370        380        390 
ANALLDTFGS DQLPLIQAAV ERHHAASKEF

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD64427.1.
RefSeqYP_175388.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WGS8.
SMRQ5WGS8. Positions 1-390.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WGS8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000046971; EBBACP00000045732; EBBACG00000046962.
GeneID3201726.
GenomeReviewsGene locus ABC1892 in contig AP006627_GR.
KEGGbcl:ABC1892.
NMPDRfig|66692.3.peg.1936.
PATRIC18923304. VBIBacCla58185_2015.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0082.
GeneTreeEBGT00050000002373.
HOGENOMHBG292336.
OMAMLRWLTA.
ProtClustDBPRK05382.

Enzyme and pathway databases

BioCycBCLA66692:ABC1892-MONOMER.

Family and domain databases

HAMAPMF_00300. Chorismate_synth.
[Tree]
InterProIPR000453. Chorismate_synth.
IPR020541. Chorismate_synthase_CS.
[Graphical view]
KOK01736.
PANTHERPTHR21085. Chorismate_synth. 1 hit.
PfamPF01264. Chorismate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001456. Chorismate_synth. 1 hit.
SUPFAMSSF103263. Chorismate_synth. 1 hit.
TIGRFAMsTIGR00033. AroC. 1 hit.
PROSITEPS00787. CHORISMATE_SYNTHASE_1. 1 hit.
PS00788. CHORISMATE_SYNTHASE_2. 1 hit.
PS00789. CHORISMATE_SYNTHASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROC_BACSK
AccessionPrimary (citable) accession number: Q5WGS8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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