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Q5WGS7 (AROB_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:ABC1893
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3583583-dehydroquinate synthase HAMAP MF_00110
PRO_0000231065

Sequences

Sequence LengthMass (Da)Tools
Q5WGS7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 7FC2BC1DFFF252E2

FASTA35839,100
        10         20         30         40         50         60 
MFVDIHTSSK QYKAEVGSGI LREAGKTIEA LAPASSYLIV SDENVANRYL DVLVSSFSKE 

        70         80         90        100        110        120 
PHTFVVKAGE QSKSFHVYEQ LAAFCLEKQL DRQSVIIAFG GGVVGDLAGF VAGTYMRGVR 

       130        140        150        160        170        180 
FIQVPTTLLA HDSSVGGKVA VNLPAAKNMI GVFHQPEAVL FDTELLATLP EHEWRSGFAE 

       190        200        210        220        230        240 
IVKLGFIADA SFLAWLRETV PALTSIKADN LQKMVAKAIA IKADIVGKDE KEHGIRAHLN 

       250        260        270        280        290        300 
FGHTLAHAIE AELGYGKITH GEAVAIGMRF AFRLSLRFTK EDLRLADYEE WFSALGYDLR 

       310        320        330        340        350 
LPAGLSAQRL LARMKSDKKT NAGKIVMVLL AQLGAAYTKT VDEHLLLELL EEELGGRS

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD64428.1.
RefSeqYP_175389.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WGS7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WGS7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000048815; EBBACP00000047576; EBBACG00000048806.
GeneID3201722.
GenomeReviewsGene locus ABC1893 in contig AP006627_GR.
KEGGbcl:ABC1893.
NMPDRfig|66692.3.peg.1937.
PATRIC18923306. VBIBacCla58185_2016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
GeneTreeEBGT00050000002325.
HOGENOMHBG632303.
OMAHATIVED.
ProtClustDBCLSK2767540.

Enzyme and pathway databases

BioCycBCLA66692:ABC1893-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BACSK
AccessionPrimary (citable) accession number: Q5WGS7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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