Q5WGS3 (TRPC_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	ABC1897

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018441

Sequences

	Sequence		Length	Mass (Da)
	Q5WGS3 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: DDEC9F2498375B05	FASTA	255	27,959
	10 20 30 40 50 60 MLEKILATKR EEISQLQLPE KQYFPKKSLK ASLQKTSLPL GLIAEIKQAS PSKGVLCETI 70 80 90 100 110 120 SPTAIARVYE EGGASAISVL TDRTYFQGDT AYVAEVKKTV SLPVLRKDFI LSPLQVEETA 130 140 150 160 170 180 CIGADAMLLI AGAMEAKQLH ELYELAYSKG LECLVEVHSE EELESLLAVF TPEVIGINNR 190 200 210 220 230 240 NLKTFQTSVS QTEQIAKMVP KEALLVSESG IHTPDDIARV KKAGANAVLI GEQLMRKDDK 250 RQAIIDLFSE SAINQ

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD64432.1.
RefSeq	YP_175393.1. NC_006582.1.
3D structure databases
HSSP	HSSP built from PDB template 1J5T based on UniProtKB Q56319.
ProteinModelPortal	Q5WGS3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WGS3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000049279; EBBACP00000048040; EBBACG00000049270.
GeneID	3203562.
GenomeReviews	Gene locus ABC1897 in contig AP006627_GR.
KEGG	bcl:ABC1897.
NMPDR	fig|66692.3.peg.1941.
PATRIC	18923314. VBIBacCla58185_2020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000001798.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC1897-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACSK

Accession

Primary (citable) accession number: Q5WGS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program