Reviewed, UniProtKB/Swiss-Prot Q5WGQ4 (DAPB_BACSK)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	ABC1916

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228323

Sequences

	Sequence		Length	Mass (Da)
	Q5WGQ4-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 7E7A4A904899ADFF	FASTA	264	29,013
	10 20 30 40 50 60 MTRIVIAGPR GNMGQEAVKL CLREESFELV AVVDSKNDGK QLKGLQEFQQ GDVPVYTDMA 70 80 90 100 110 120 RCFAEHEPDV LIDLTAPAFG RKHMEVAFEH GVRPVVGTTG FSDEDIRDLT KLAEAKELGA 130 140 150 160 170 180 IIAPNFAIGA ILMMKFAQTA ARYMNDVEII EQHHDRKLDA PSGTAVKTAQ LIAEVRAPKK 190 200 210 220 230 240 QGHEQEREEM AGARGADFDG MKIHSVRLPG RVAHQEVLFG GVGQTLSIRH DSLNRESFMP 250 260 GVKLAVEQVV KLSTLVYGLE NLID

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD64451.1.
RefSeq	YP_175412.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WGQ4.
Genome annotation databases
GeneID	3203886.
GenomeReviews	Gene locus ABC1916 in contig AP006627_GR.
KEGG	bcl:ABC1916.
NMPDR	fig|66692.3.peg.1960.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WGQ4.
OMA	VLMMKFA.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC1916-MON.
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
ProDom	PD004105. DapB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BACSK

Accession

Primary (citable) accession number: Q5WGQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)