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Q5WG56

- ODO1_BACSK

UniProt

Q5WG56 - ODO1_BACSK

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, ABC2114
Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-2182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:ABC2114
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9439432-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_0000162168Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC2114.

Structurei

3D structure databases

ProteinModelPortaliQ5WG56.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WG56-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKEHSPEK PWRGFYGPNL GAVIELYDQY VEDPNSVDEQ TRAHFEKWGP    50
PALEENVSSS NAKETIGADM ISAVVGAVRL ADYIRAKGHL VSDIQPIWKT 100
DKNSNLLDYD RFNVTEEELK KVPVKLICKD APPHLKNGLE AIEHLKKVYT 150
QTMAFEFGHV QDEEERNWLR KQVESEAYAD ELPNKEKKAL LERLTSVEGF 200
EKFIHRTFVG QKRFSIEGLD TLVPMLDKAI REVRKEKTDH VMIGMAHRGR 250
LNVLAHTLGK PYKAIFSEFL QAPNKLNAPS EGLGETYTGW TGDVKYHLGA 300
DRQISDDKSA QTIVSLANNP SHLEFVSPIV EGYARAAQED RSSKGAPKQD 350
TTRAYSILIH GDAAFPGQGV VTETLNLSRL NGYHVGGSLH IIANNNIGYT 400
TEMHDSRSTT YASDPAKGFE IPIVHVNADD AEACVRAIKF AVEYRRKFQK 450
DFLIDLIGYR RFGHNEGDEP AVTQPDLYAQ IRKHPTVRAI YAKQLEAEQV 500
ITAKEAQKLD TDMYNYLLEE YNKVNSDKSE KKYELSPPDF IVDGLPKVKT 550
AVEKEKLVAM NEQLLDWPSS FKPNQKLEKI LKRRANAFDG EGNVDWGLAE 600
ILAFASILHD GTPVRLSGQD SERGTFAHRH FVLHDRETNE THVPLQTIKD 650
ANASFAVYNS PLTEQACVGF EYGYNVFSKE TLVLWEAQFG DFVNGAQVMF 700
DQWVSAGRAK WGQKSGLVVL LPHGYEGAGP EHSSGRVERF LSSAAENNWT 750
VANCTSAAQY FHILRRQAKI LQKNTVRPLI IMTPKSLLRN QVVASPTSAF 800
TEGEFQPILE EPTLGHDPNA VKRIILCSGK LAIELQDYVN KNDEDWSWVH 850
IIRVEELYPF PRRAIRERLK EFPNLEEVKW VQEEPKNMGA WTFMEPRIRE 900
ILPSGVPLSY IGRTYRSSPA EGVSNAHKVE QKRIVTESLT RKN 943
Length:943
Mass (Da):106,584
Last modified:November 23, 2004 - v1
Checksum:i3FF67A61E3A2C6D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD64649.1.
RefSeqiYP_175610.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD64649; BAD64649; ABC2114.
GeneIDi3202055.
KEGGibcl:ABC2114.
PATRICi18923786. VBIBacCla58185_2256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD64649.1 .
RefSeqi YP_175610.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WG56.
ModBasei Search...

Protein-protein interaction databases

STRINGi 66692.ABC2114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD64649 ; BAD64649 ; ABC2114 .
GeneIDi 3202055.
KEGGi bcl:ABC2114.
PATRICi 18923786. VBIBacCla58185_2256.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-2182-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiODO1_BACSK
AccessioniPrimary (citable) accession number: Q5WG56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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