Reviewed, UniProtKB/Swiss-Prot Q5WG56 (ODO1_BACSK)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	ABC2114

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	943 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 943	943	2-oxoglutarate dehydrogenase E1 component		PRO_0000162168

Sequences

	Sequence		Length	Mass (Da)
	Q5WG56-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 3FF67A61E3A2C6D8	FASTA	943	106,584
	10 20 30 40 50 60 MSSKEHSPEK PWRGFYGPNL GAVIELYDQY VEDPNSVDEQ TRAHFEKWGP PALEENVSSS 70 80 90 100 110 120 NAKETIGADM ISAVVGAVRL ADYIRAKGHL VSDIQPIWKT DKNSNLLDYD RFNVTEEELK 130 140 150 160 170 180 KVPVKLICKD APPHLKNGLE AIEHLKKVYT QTMAFEFGHV QDEEERNWLR KQVESEAYAD 190 200 210 220 230 240 ELPNKEKKAL LERLTSVEGF EKFIHRTFVG QKRFSIEGLD TLVPMLDKAI REVRKEKTDH 250 260 270 280 290 300 VMIGMAHRGR LNVLAHTLGK PYKAIFSEFL QAPNKLNAPS EGLGETYTGW TGDVKYHLGA 310 320 330 340 350 360 DRQISDDKSA QTIVSLANNP SHLEFVSPIV EGYARAAQED RSSKGAPKQD TTRAYSILIH 370 380 390 400 410 420 GDAAFPGQGV VTETLNLSRL NGYHVGGSLH IIANNNIGYT TEMHDSRSTT YASDPAKGFE 430 440 450 460 470 480 IPIVHVNADD AEACVRAIKF AVEYRRKFQK DFLIDLIGYR RFGHNEGDEP AVTQPDLYAQ 490 500 510 520 530 540 IRKHPTVRAI YAKQLEAEQV ITAKEAQKLD TDMYNYLLEE YNKVNSDKSE KKYELSPPDF 550 560 570 580 590 600 IVDGLPKVKT AVEKEKLVAM NEQLLDWPSS FKPNQKLEKI LKRRANAFDG EGNVDWGLAE 610 620 630 640 650 660 ILAFASILHD GTPVRLSGQD SERGTFAHRH FVLHDRETNE THVPLQTIKD ANASFAVYNS 670 680 690 700 710 720 PLTEQACVGF EYGYNVFSKE TLVLWEAQFG DFVNGAQVMF DQWVSAGRAK WGQKSGLVVL 730 740 750 760 770 780 LPHGYEGAGP EHSSGRVERF LSSAAENNWT VANCTSAAQY FHILRRQAKI LQKNTVRPLI 790 800 810 820 830 840 IMTPKSLLRN QVVASPTSAF TEGEFQPILE EPTLGHDPNA VKRIILCSGK LAIELQDYVN 850 860 870 880 890 900 KNDEDWSWVH IIRVEELYPF PRRAIRERLK EFPNLEEVKW VQEEPKNMGA WTFMEPRIRE 910 920 930 940 ILPSGVPLSY IGRTYRSSPA EGVSNAHKVE QKRIVTESLT RKN

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD64649.1.
RefSeq	YP_175610.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3202055.
GenomeReviews	Gene locus ABC2114 in contig AP006627_GR.
KEGG	bcl:ABC2114.
NMPDR	fig|66692.3.peg.2418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WG56.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2114-MON.
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DHase_E1. IPR001017. DHase_E1. IPR005475. Transketo_Cen_R. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_BACSK

Accession

Primary (citable) accession number: Q5WG56

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	November 23, 2004
Last modified:	November 4, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)