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Q5WG56 (ODO1_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
Ordered Locus Names:ABC2114
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length943 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9439432-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_0000162168

Sequences

Sequence LengthMass (Da)Tools
Q5WG56 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 3FF67A61E3A2C6D8

FASTA943106,584
        10         20         30         40         50         60 
MSSKEHSPEK PWRGFYGPNL GAVIELYDQY VEDPNSVDEQ TRAHFEKWGP PALEENVSSS 

        70         80         90        100        110        120 
NAKETIGADM ISAVVGAVRL ADYIRAKGHL VSDIQPIWKT DKNSNLLDYD RFNVTEEELK 

       130        140        150        160        170        180 
KVPVKLICKD APPHLKNGLE AIEHLKKVYT QTMAFEFGHV QDEEERNWLR KQVESEAYAD 

       190        200        210        220        230        240 
ELPNKEKKAL LERLTSVEGF EKFIHRTFVG QKRFSIEGLD TLVPMLDKAI REVRKEKTDH 

       250        260        270        280        290        300 
VMIGMAHRGR LNVLAHTLGK PYKAIFSEFL QAPNKLNAPS EGLGETYTGW TGDVKYHLGA 

       310        320        330        340        350        360 
DRQISDDKSA QTIVSLANNP SHLEFVSPIV EGYARAAQED RSSKGAPKQD TTRAYSILIH 

       370        380        390        400        410        420 
GDAAFPGQGV VTETLNLSRL NGYHVGGSLH IIANNNIGYT TEMHDSRSTT YASDPAKGFE 

       430        440        450        460        470        480 
IPIVHVNADD AEACVRAIKF AVEYRRKFQK DFLIDLIGYR RFGHNEGDEP AVTQPDLYAQ 

       490        500        510        520        530        540 
IRKHPTVRAI YAKQLEAEQV ITAKEAQKLD TDMYNYLLEE YNKVNSDKSE KKYELSPPDF 

       550        560        570        580        590        600 
IVDGLPKVKT AVEKEKLVAM NEQLLDWPSS FKPNQKLEKI LKRRANAFDG EGNVDWGLAE 

       610        620        630        640        650        660 
ILAFASILHD GTPVRLSGQD SERGTFAHRH FVLHDRETNE THVPLQTIKD ANASFAVYNS 

       670        680        690        700        710        720 
PLTEQACVGF EYGYNVFSKE TLVLWEAQFG DFVNGAQVMF DQWVSAGRAK WGQKSGLVVL 

       730        740        750        760        770        780 
LPHGYEGAGP EHSSGRVERF LSSAAENNWT VANCTSAAQY FHILRRQAKI LQKNTVRPLI 

       790        800        810        820        830        840 
IMTPKSLLRN QVVASPTSAF TEGEFQPILE EPTLGHDPNA VKRIILCSGK LAIELQDYVN 

       850        860        870        880        890        900 
KNDEDWSWVH IIRVEELYPF PRRAIRERLK EFPNLEEVKW VQEEPKNMGA WTFMEPRIRE 

       910        920        930        940 
ILPSGVPLSY IGRTYRSSPA EGVSNAHKVE QKRIVTESLT RKN 

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References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006627 Genomic DNA. Translation: BAD64649.1.
RefSeqYP_175610.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WG56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING66692.ABC2114.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD64649; BAD64649; ABC2114.
GeneID3202055.
KEGGbcl:ABC2114.
PATRIC18923786. VBIBacCla58185_2256.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMANEGVANE.
OrthoDBEOG6V1M1F.
ProtClustDBPRK09404.

Enzyme and pathway databases

BioCycBCLA66692:GHMP-2182-MONOMER.

Family and domain databases

HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_BACSK
AccessionPrimary (citable) accession number: Q5WG56
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families