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Q5WG56

- ODO1_BACSK

UniProt

Q5WG56 - ODO1_BACSK

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-2182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:ABC2114
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9439432-oxoglutarate dehydrogenase E1 componentPRO_0000162168Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC2114.

Structurei

3D structure databases

ProteinModelPortaliQ5WG56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WG56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKEHSPEK PWRGFYGPNL GAVIELYDQY VEDPNSVDEQ TRAHFEKWGP
60 70 80 90 100
PALEENVSSS NAKETIGADM ISAVVGAVRL ADYIRAKGHL VSDIQPIWKT
110 120 130 140 150
DKNSNLLDYD RFNVTEEELK KVPVKLICKD APPHLKNGLE AIEHLKKVYT
160 170 180 190 200
QTMAFEFGHV QDEEERNWLR KQVESEAYAD ELPNKEKKAL LERLTSVEGF
210 220 230 240 250
EKFIHRTFVG QKRFSIEGLD TLVPMLDKAI REVRKEKTDH VMIGMAHRGR
260 270 280 290 300
LNVLAHTLGK PYKAIFSEFL QAPNKLNAPS EGLGETYTGW TGDVKYHLGA
310 320 330 340 350
DRQISDDKSA QTIVSLANNP SHLEFVSPIV EGYARAAQED RSSKGAPKQD
360 370 380 390 400
TTRAYSILIH GDAAFPGQGV VTETLNLSRL NGYHVGGSLH IIANNNIGYT
410 420 430 440 450
TEMHDSRSTT YASDPAKGFE IPIVHVNADD AEACVRAIKF AVEYRRKFQK
460 470 480 490 500
DFLIDLIGYR RFGHNEGDEP AVTQPDLYAQ IRKHPTVRAI YAKQLEAEQV
510 520 530 540 550
ITAKEAQKLD TDMYNYLLEE YNKVNSDKSE KKYELSPPDF IVDGLPKVKT
560 570 580 590 600
AVEKEKLVAM NEQLLDWPSS FKPNQKLEKI LKRRANAFDG EGNVDWGLAE
610 620 630 640 650
ILAFASILHD GTPVRLSGQD SERGTFAHRH FVLHDRETNE THVPLQTIKD
660 670 680 690 700
ANASFAVYNS PLTEQACVGF EYGYNVFSKE TLVLWEAQFG DFVNGAQVMF
710 720 730 740 750
DQWVSAGRAK WGQKSGLVVL LPHGYEGAGP EHSSGRVERF LSSAAENNWT
760 770 780 790 800
VANCTSAAQY FHILRRQAKI LQKNTVRPLI IMTPKSLLRN QVVASPTSAF
810 820 830 840 850
TEGEFQPILE EPTLGHDPNA VKRIILCSGK LAIELQDYVN KNDEDWSWVH
860 870 880 890 900
IIRVEELYPF PRRAIRERLK EFPNLEEVKW VQEEPKNMGA WTFMEPRIRE
910 920 930 940
ILPSGVPLSY IGRTYRSSPA EGVSNAHKVE QKRIVTESLT RKN
Length:943
Mass (Da):106,584
Last modified:November 23, 2004 - v1
Checksum:i3FF67A61E3A2C6D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD64649.1.
RefSeqiYP_175610.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD64649; BAD64649; ABC2114.
GeneIDi3202055.
KEGGibcl:ABC2114.
PATRICi18923786. VBIBacCla58185_2256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD64649.1 .
RefSeqi YP_175610.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WG56.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC2114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD64649 ; BAD64649 ; ABC2114 .
GeneIDi 3202055.
KEGGi bcl:ABC2114.
PATRICi 18923786. VBIBacCla58185_2256.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-2182-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiODO1_BACSK
AccessioniPrimary (citable) accession number: Q5WG56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3