Reviewed, UniProtKB/Swiss-Prot Q5WFI9 (PYRB_BACSK)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	ABC2336

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Aspartate carbamoyltransferase		PRO_0000113098

Sequences

	Sequence		Length	Mass (Da)
	Q5WFI9-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: C5FFB57004E44C55	FASTA	301	33,345
	10 20 30 40 50 60 MLSAQIEKAT QKGLCTMNEM GVSEVLDLLK TAESFAAGAV WKPRMQLFVA NLFFEPSTRT 70 80 90 100 110 120 RFSFEVAERR LGLEVLQFDG QHASTQKGES LYDTARTLES IGASALVIRH RQDAYFHELK 130 140 150 160 170 180 GLSVPIINAG DGCGNHPTQS LLDLLTIKQE FSSFSGLHVV IAGDLAHSRV ARSNADILTR 190 200 210 220 230 240 LGARVSVAGP IEWMGEFTDT YTHVSMDEAA RQADVLMMLR VQHERHDDNA LFSKEAYHQA 250 260 270 280 290 300 YGLTEQREAL MAKQSIIMHP APVNRDVEIA SVLVECKRSR IYKQSANGVA VRMAVLKRAL A

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD64871.1.
RefSeq	YP_175832.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3202824.
GenomeReviews	Gene locus ABC2336 in contig AP006627_GR.
KEGG	bcl:ABC2336.
NMPDR	fig|66692.3.peg.2024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WFI9.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2336-MON.
Family and domain databases
HAMAP	MF_00001. [Tree]
InterPro	IPR006130. Asp/Orn_carbamoyltranf. IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Aspartate_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
ProDom	PD000902. Enolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACSK

Accession

Primary (citable) accession number: Q5WFI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	November 23, 2004
Last modified:	November 25, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)