Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5WFG7 (MRAY_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:ABC2358
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108782

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane57 – 7721Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane252 – 27221Helical; Potential
Transmembrane302 – 32221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5WFG7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C3585C5115FA6200

FASTA32534,878
        10         20         30         40         50         60 
MEEWTLLFVL ILSFAAAVIM SPLFIPFLRK LKFGQSIREE GPKSHQKKSG TPTMGGIVIV 

        70         80         90        100        110        120 
LSIFISALAI GIAITGFTPE LLLLMVVTLG YGIVGFVDDY LKVVRKHNLG LTSKQKLAGQ 

       130        140        150        160        170        180 
LVIAAIFYIG LLAIGFDTFI AIPGTTFGFD LGWLYLILIV LMLLGASNAV NLTDGLDGLL 

       190        200        210        220        230        240 
AGTGSIAFGA FAILAWSGGF IDTALFSTAI TGALLGFLVF NAHPAKVFMG DTGSLALGGA 

       250        260        270        280        290        300 
IAAIAILTKM ELMLIIVGGV FVIETLSVII QVASFKLTGK RVFRMSPLHH HYELVGWSEW 

       310        320 
RVVVTFWLVG MIFAIMGVYI GVWLT

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD64893.1.
RefSeqYP_175854.1. NC_006582.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WFG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000046815; EBBACP00000045576; EBBACG00000046806.
GeneID3204468.
GenomeReviewsGene locus ABC2358 in contig AP006627_GR.
KEGGbcl:ABC2358.
NMPDRfig|66692.3.peg.2046.
PATRIC18924306. VBIBacCla58185_2516.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
GeneTreeEBGT00050000001191.
HOGENOMHBG708263.
OMAQVGYFKW.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBCLA66692:ABC2358-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BACSK
AccessionPrimary (citable) accession number: Q5WFG7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents