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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:ABC2358
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

Subcellular locationi

  • Cell membrane ; Multi-pass membrane protein

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalAdd BLAST21
Transmembranei57 – 77HelicalAdd BLAST21
Transmembranei81 – 101HelicalAdd BLAST21
Transmembranei122 – 142HelicalAdd BLAST21
Transmembranei146 – 166HelicalAdd BLAST21
Transmembranei186 – 206HelicalAdd BLAST21
Transmembranei227 – 247HelicalAdd BLAST21
Transmembranei252 – 272HelicalAdd BLAST21
Transmembranei302 – 322HelicalAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001087821 – 325Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST325

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2358.

Structurei

3D structure databases

SMRiQ5WFG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WFG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWTLLFVL ILSFAAAVIM SPLFIPFLRK LKFGQSIREE GPKSHQKKSG
60 70 80 90 100
TPTMGGIVIV LSIFISALAI GIAITGFTPE LLLLMVVTLG YGIVGFVDDY
110 120 130 140 150
LKVVRKHNLG LTSKQKLAGQ LVIAAIFYIG LLAIGFDTFI AIPGTTFGFD
160 170 180 190 200
LGWLYLILIV LMLLGASNAV NLTDGLDGLL AGTGSIAFGA FAILAWSGGF
210 220 230 240 250
IDTALFSTAI TGALLGFLVF NAHPAKVFMG DTGSLALGGA IAAIAILTKM
260 270 280 290 300
ELMLIIVGGV FVIETLSVII QVASFKLTGK RVFRMSPLHH HYELVGWSEW
310 320
RVVVTFWLVG MIFAIMGVYI GVWLT
Length:325
Mass (Da):34,878
Last modified:November 23, 2004 - v1
Checksum:iC3585C5115FA6200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD64893.1.
RefSeqiWP_011247201.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD64893; BAD64893; ABC2358.
GeneIDi34043871.
KEGGibcl:ABC2358.

Similar proteinsi

Entry informationi

Entry nameiMRAY_BACSK
AccessioniPrimary (citable) accession number: Q5WFG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families