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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:ABC2494
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669601 – 448Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST448

Proteomic databases

PRIDEiQ5WF31

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC2494

Structurei

3D structure databases

ProteinModelPortaliQ5WF31
SMRiQ5WF31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WF31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTHRYLPMT EEDKKEMLAT IGVDSIEALF ADIPESTRFK SQLAIEAALK
60 70 80 90 100
EPELIAHFQK LADENQSIKT YTSFLGAGVY EHYIPSIVDH VISRSEFYTA
110 120 130 140 150
YTPYQPEISQ GELQAIFEFQ TMICELTGMD IANSSMYDGP TALAEAAMLS
160 170 180 190 200
CGHTKKKTIL VSKAVHPEAR AVLKTNAYGQ RLNVIEIDAN ANVTDIESLK
210 220 230 240 250
AAYNDEVACV IVQHPNFYGS LEPLAEIEEI VHQGKAQFVV SSNPLALGVL
260 270 280 290 300
KPPGDFGADI VVGDAQPFGI PVQFGGPHCG YFATTKKLMR KIPGRLVGQT
310 320 330 340 350
VDEEGRRGFV LTLQAREQHI RREKATSNIC SNQALNALAA SVAMTALGKQ
360 370 380 390 400
GVKEMAKQNV QKSAYLKKQL SLAGIDVVGD GPTFNEFVIN CGQPVKDVNR
410 420 430 440
QLLEKGMIGG FDLGSVEPER NGQMLVCVTE LRTKEELDLF ANEMGALV
Length:448
Mass (Da):48,989
Last modified:November 23, 2004 - v1
Checksum:iC9206A5FE8279697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD65029.1

Genome annotation databases

EnsemblBacteriaiBAD65029; BAD65029; ABC2494
KEGGibcl:ABC2494

Similar proteinsi

Entry informationi

Entry nameiGCSPA_BACSK
AccessioniPrimary (citable) accession number: Q5WF31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health