Reviewed, UniProtKB/Swiss-Prot Q5WF30 (GCST_BACSK)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	ABC2495

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Aminomethyltransferase HAMAP MF_00259		PRO_0000122542

Sequences

	Sequence		Length	Mass (Da)
	Q5WF30-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 6BFF261BDD9F3ED8	FASTA	367	40,129
	10 20 30 40 50 60 METKLLRTPL YELYDQAGAK TVDFGGWELP VSFSGIKKEH HAVRNAAGLF DVSHMGELLV 70 80 90 100 110 120 EGPDALNNLQ ALVTNDLSKL QDNQAQYNAM CTESGGTVDD LIVYRRNENA YLLVLNAANI 130 140 150 160 170 180 QSDIEWIRAH VSGQVTLTDI SNETALLAVQ GPKALAVLQT LTDEPLSEIR PFRFKENVMF 190 200 210 220 230 240 AAIPVLASRT GYTGEDGFEL YVKAGDAAEL WRAILAAGEP FGLLPCGLGA RDTLRFEARL 250 260 270 280 290 300 PLYGQELTKD ISPIEAGIGF AVKTDKQAAF IGQQALKKQK EQGPSRKLVG IEMVDRGIPR 310 320 330 340 350 360 TGYRVFYQGQ DVGFVTSGTQ SPTLGKNVGL VLAKADAAAI DTELEVEVRG KRLRARVVKT PFYKRTK

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD65030.1.
RefSeq	YP_175991.1.
3D structure databases
SMR	Q5WF30. Positions 5-362.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WF30.
Genome annotation databases
GeneID	3202195.
GenomeReviews	Gene locus ABC2495 in contig AP006627_GR.
KEGG	bcl:ABC2495.
NMPDR	fig|66692.3.peg.2182.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2495-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACSK

Accession

Primary (citable) accession number: Q5WF30

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)