Reviewed, UniProtKB/Swiss-Prot Q5WF06 (PPNK_BACSK)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase
      Short name=Poly(P)/ATP NAD kinase
    EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	ABC2519

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229603

Sequences

	Sequence		Length	Mass (Da)
	Q5WF06-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: FE9A5EFCB8B3D08B	FASTA	267	29,863
	10 20 30 40 50 60 MKFTVASRGD TLSDELCDTI KTRLLAADLA HDSDKPDIVI TVGGDGTFLE AFHSYAHRLE 70 80 90 100 110 120 ETAFVGIHTG HLGFYADWVP EETEHLITHI IKTPFQIVEY PLLEVVIRYR GGQREPRRHL 130 140 150 160 170 180 ALNESTIKST EGSLVCTVEI KGEAFETFRG DGLCMSTPSG STAYNKALGG AILHPSLASI 190 200 210 220 230 240 QLSEMASINN RIYRTLGSPL VLPQHHTCLL KLLNDVSVQV TIDHFNVPVF AENVDTIQVR 250 260 VAEEKVRFAR FRPFPFWKRV KEAFISE

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD65054.1.
RefSeq	YP_176015.1.
3D structure databases
SMR	Q5WF06. Positions 1-265.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WF06.
Genome annotation databases
GeneID	3201676.
GenomeReviews	Gene locus ABC2519 in contig AP006627_GR.
KEGG	bcl:ABC2519.
NMPDR	fig|66692.3.peg.2207.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HBG314020.
OMA	EVIIRYV.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2519-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK_BACSK

Accession

Primary (citable) accession number: Q5WF06

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 23, 2004
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)