Q5WEW9 (ARGB_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	ABC2556

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC glutamate 5-kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000112585
Regions
	Region	40 – 41	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Site	7	1	Transition state stabilizer By similarity
	Site	214	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WEW9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 2D93B1902D1717FB	FASTA	257	26,714
	10 20 30 40 50 60 MATVVIKIGG STLEALEEGF YEGVVKRASL GDKIMIVHGG GPAINNLLQA MAVESQFVNG 70 80 90 100 110 120 LRKTTAEVLT AAETALSGQI NKQLVRSLYQ AGGKAIGLSG SDGHLLKTIP IDTDKLGFVG 130 140 150 160 170 180 AVESVNVDVL FNVAKAGYIP VIAPIGMDAN YQPYNINADT AAAAVAKASK AEELVFVTDV 190 200 210 220 230 240 DGVQKDGKVI KEMDEVLAKH YIEEGVIYGG MVPKVNACLD SLSGALTKAR IVNGKKAYHP 250 SAGTAIVKQS NVLTSGA

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD65091.1.
RefSeq	YP_176052.1. NC_006582.1.
3D structure databases
ProteinModelPortal	Q5WEW9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WEW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000047338; EBBACP00000046099; EBBACG00000047329.
GeneID	3201713.
GenomeReviews	Gene locus ABC2556 in contig AP006627_GR.
KEGG	bcl:ABC2556.
NMPDR	fig|66692.3.peg.2244.
PATRIC	18924754. VBIBacCla58185_2729.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0548.
GeneTree	EBGT00050000001971.
HOGENOM	HBG497643.
OMA	GGNAMID.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2556-MONOMER.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. IPR001057. Glu/AcGlu_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
PRINTS	PR00474. GLU5KINASE.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_BACSK

Accession

Primary (citable) accession number: Q5WEW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program