Reviewed, UniProtKB/Swiss-Prot Q5WEW7 (ARGC_BACSK)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	ABC2558

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112383
Sites
	Active site	149	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WEW7-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 62E29BA004C86AFD	FASTA	344	37,707
	10 20 30 40 50 60 MEVGIIGATG YSGLELIRLL KNHPQVTNIM LYSSSQSGET INRLYPHLQN EQWKPLKEID 70 80 90 100 110 120 LNKISAEIDV MFLATPPGVS AEWSGPLLEA GLSVIDLSGD LRLTDRGVYE KWYKRPSAKE 130 140 150 160 170 180 GLIEQAIYGL SEWNKSTIKT AKLIANPGCF PTAALLALIP LIQAGAIERD SIVIDAKSGT 190 200 210 220 230 240 SGAGKSPTSM THFSETNENF KIYQVASHKH TPEIEQQLAK WGAQPPLSFQ PHLAPMVRGI 250 260 270 280 290 300 MATIYAKAAK PLSNEWLTDC YNSAYENAPF VRIKENGTFP ATKHVFGSNY CDIGFCYDER 310 320 330 340 TGRVIVASVI DNLMKGAAGQ AVQNFNLMHG FDETAGLEAV PMYP

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD65093.1.
RefSeq	YP_176054.1.
3D structure databases
SMR	Q5WEW7. Positions 1-344.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WEW7.
Genome annotation databases
GeneID	3201714.
GenomeReviews	Gene locus ABC2558 in contig AP006627_GR.
KEGG	bcl:ABC2558.
NMPDR	fig|66692.3.peg.2246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0002.
HOGENOM	HBG294213.
OMA	VCRIAVH.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2558-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BACSK

Accession

Primary (citable) accession number: Q5WEW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)