Reviewed, UniProtKB/Swiss-Prot Q5WEM4 (NTPA_BACSK)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

ABC2651

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Nucleoside-triphosphatase		PRO_0000178128

Sequences

	Sequence		Length	Mass (Da)
	Q5WEM4-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 03FCDFD235EF0D6B	FASTA	198	21,585
	10 20 30 40 50 60 MNELVVATKN KGKLADFQTL FTDRYIVKSL YDYPEVPEII EDGDTFHENA AKKAETLAAY 70 80 90 100 110 120 LQKLVIADDS GLLIDALGGK PGVYSARYAG EPKNDQANID KVLSELDGVP TQKRTARFFC 130 140 150 160 170 180 VIALAEPGKE TIFAEGACEG RITEKPTGSN GFGYDPIFFV PSHGQTMAEL SAGTKNQLSH 190 RARALTALKE TIEGVWPK

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD65186.1.
RefSeq	YP_176147.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3204761.
GenomeReviews	Gene locus ABC2651 in contig AP006627_GR.
KEGG	bcl:ABC2651.
NMPDR	fig|66692.3.peg.2974.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WEM4.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2651-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BACSK

Accession

Primary (citable) accession number: Q5WEM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 23, 2004
Last modified:	July 22, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)