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Q5WEG2

- MDH_BACSK

UniProt

Q5WEG2 - MDH_BACSK

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NADUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei100 – 1001NADUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Active sitei180 – 1801Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NADUniRule annotation
Nucleotide bindingi123 – 1253NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-2794-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:ABC2713
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Malate dehydrogenasePRO_0000113433Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei149 – 1491PhosphoserineUniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2713.

Structurei

3D structure databases

ProteinModelPortaliQ5WEG2.
SMRiQ5WEG2. Positions 5-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYGQNDIC.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WEG2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIKRRKISV IGSGFTGATT ALMVAQKELG DVVLLDIPNM EGPTKGKALD
60 70 80 90 100
MLESTPVQGV DSTITGTSSY EDTKDSDVVV ITAGIARKPG MSRDDLVATN
110 120 130 140 150
AKIMKSVTKE VVKYSPNSYI IVLTNPADAM TYTVYKESGF PKNRVIGQSG
160 170 180 190 200
VLDTARFRTF VAQELNVSVE DVTGFVLGGH GDDMVPLIRY SAAGGVPLTK
210 220 230 240 250
LIAPERIEEI VERTRKGGGE IVGLLGNGSA YYAPAASLTQ MVEAILKDKK
260 270 280 290 300
RIIPTIAYLE GEYGQHDLYL GVPTILGGDG IEKVIELDLT EEEKAQLDKS
310
VQSVRNVMAA LPAE
Length:314
Mass (Da):33,597
Last modified:November 23, 2004 - v1
Checksum:iED99F51CA5F3F8D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65248.1.
RefSeqiYP_176209.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD65248; BAD65248; ABC2713.
GeneIDi3204432.
KEGGibcl:ABC2713.
PATRICi18925084. VBIBacCla58185_2892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65248.1 .
RefSeqi YP_176209.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WEG2.
SMRi Q5WEG2. Positions 5-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC2713.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD65248 ; BAD65248 ; ABC2713 .
GeneIDi 3204432.
KEGGi bcl:ABC2713.
PATRICi 18925084. VBIBacCla58185_2892.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YGQNDIC.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-2794-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiMDH_BACSK
AccessioniPrimary (citable) accession number: Q5WEG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3