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Q5WED9 (ARLY2_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase 2
Short name=ASAL 2
EC=4.3.2.1
Alternative name(s):
Arginosuccinase 2
Gene names
Name:argH2
Ordered Locus Names:ABC2736
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Argininosuccinate lyase 2 HAMAP MF_00006
PRO_0000240713

Sequences

Sequence LengthMass (Da)Tools
Q5WED9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 477E236E219BC471

FASTA46251,026
        10         20         30         40         50         60 
MSKLWGGRFT KTAEQWVDEF GASIGFDQQL VEEDITGSIA HVTMLAKQHI LSEEEAAQIK 

        70         80         90        100        110        120 
NGLKTLQKKA AAGELVFSAA QEDIHLNLEK LLIDEIGPVG GKLHTGRSRN DQVATDMHLY 

       130        140        150        160        170        180 
LRTQTEEIME AIRTLQAALV KQAEGHVETL IPGYTHLQRA QPVSFAHHLL AYFWMLERDY 

       190        200        210        220        230        240 
GRLQDSLKRV NISPLGAGAL AGTTFPIDRA YTAELLHFEG IYENSLDAVS DRDFIVEFLA 

       250        260        270        280        290        300 
ASATLMMHLS RLCEELILWS AQEFQFIEID DAFATGSSIM PQKKNPDMAE LIRGKTGRVY 

       310        320        330        340        350        360 
GSLFSLLTTL KGLPLAYNKD MQEDKEGMFD TVKTVKGSLR IFAGMIETIT VNTDAMAKAV 

       370        380        390        400        410        420 
TSDFSNATEL ADYLATKGMP FREAHEVVGK LVLTAIEKGV YLLDLPIEVY KEASSLFADD 

       430        440        450        460 
IYEVLQPKTV VGRRNSAGGT GFEQVKLALG KANDLLSQSI KG

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD65271.1.
RefSeqYP_176232.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WED9.
SMRQ5WED9. Positions 14-456.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WED9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000046430; EBBACP00000045191; EBBACG00000046421.
GeneID3201718.
GenomeReviewsGene locus ABC2736 in contig AP006627_GR.
KEGGbcl:ABC2736.
NMPDRfig|66692.3.peg.2592.
PATRIC18925130. VBIBacCla58185_2915.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
GeneTreeEBGT00070000031828.
HOGENOMHBG539632.
OMAEDIHTVI.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycBCLA66692:ABC2736-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY2_BACSK
AccessionPrimary (citable) accession number: Q5WED9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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