Reviewed, UniProtKB/Swiss-Prot Q5WED5 (ACKA_BACSK)

Names and origin

Protein names

Recommended name:
    Acetate kinase
    EC=2.7.2.1
Alternative name(s):
    Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	ABC2740

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Acetate kinase HAMAP MF_00020		PRO_0000107533

Sequences

	Sequence		Length	Mass (Da)
	Q5WED5-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: F8BFCE8D4665F924	FASTA	395	42,575
	10 20 30 40 50 60 MAKIIAINAG SSSLKFQLLA MPEETVIAKG LVERIGLKKS IFTIEANGQQ HELTEDIPDH 70 80 90 100 110 120 AAAVKLLLKD LTGRGIIASL EEIEGIGHRV VHGGEKFNDS VVITDEVLQG IEEVSELAPL 130 140 150 160 170 180 HNPANITGIK AFKEVLPNVP AVAVFDTAFH QTMPESAFLY SLPYEYYEKY GIRKYGFHGT 190 200 210 220 230 240 SHKYVTHRAA ELMETPIEEL RILSCHLGNG ASIAAVKGGK SIDTSMGFTP LAGVTMGTRS 250 260 270 280 290 300 GNIDPALIPY IMEKTGQSVE EVVATLNKKS GLLGITGFSS DLRDIEAAAK EGDERAQVAL 310 320 330 340 350 360 DVFASRIHKY VGSYAARMGG LDAIVFTAGI GENSATIRER VLKGLSFMGV DVDLEKNNVR 370 380 390 GKEAFIEKAG APVKIIVIPT NEEVMIARDT VRLTS

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD65275.1.
RefSeq	YP_176236.1.
3D structure databases
SMR	Q5WED5. Positions 3-394.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WED5.
Genome annotation databases
GeneID	3203528.
GenomeReviews	Gene locus ABC2740 in contig AP006627_GR.
KEGG	bcl:ABC2740.
NMPDR	fig|66692.3.peg.2596.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	IVTFLME.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2740-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR000890. Acetate/butyrate_kinase. IPR004372. AckA. [Graphical view]
PANTHER	PTHR21060. Acetate_kin. 1 hit. PTHR21060:SF11. AckA. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. ackA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_BACSK

Accession

Primary (citable) accession number: Q5WED5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)