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Protein

Acetate kinase

Gene

ackA

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi382MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi281 – 283ATPUniRule annotation3
Nucleotide bindingi329 – 333ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-2896-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:ABC2740
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075331 – 395Acetate kinaseAdd BLAST395

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC2740.

Structurei

3D structure databases

ProteinModelPortaliQ5WED5.
SMRiQ5WED5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288399.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WED5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIIAINAG SSSLKFQLLA MPEETVIAKG LVERIGLKKS IFTIEANGQQ
60 70 80 90 100
HELTEDIPDH AAAVKLLLKD LTGRGIIASL EEIEGIGHRV VHGGEKFNDS
110 120 130 140 150
VVITDEVLQG IEEVSELAPL HNPANITGIK AFKEVLPNVP AVAVFDTAFH
160 170 180 190 200
QTMPESAFLY SLPYEYYEKY GIRKYGFHGT SHKYVTHRAA ELMETPIEEL
210 220 230 240 250
RILSCHLGNG ASIAAVKGGK SIDTSMGFTP LAGVTMGTRS GNIDPALIPY
260 270 280 290 300
IMEKTGQSVE EVVATLNKKS GLLGITGFSS DLRDIEAAAK EGDERAQVAL
310 320 330 340 350
DVFASRIHKY VGSYAARMGG LDAIVFTAGI GENSATIRER VLKGLSFMGV
360 370 380 390
DVDLEKNNVR GKEAFIEKAG APVKIIVIPT NEEVMIARDT VRLTS
Length:395
Mass (Da):42,575
Last modified:November 23, 2004 - v1
Checksum:iF8BFCE8D4665F924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD65275.1.
RefSeqiWP_011247583.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD65275; BAD65275; ABC2740.
GeneIDi34044489.
KEGGibcl:ABC2740.

Similar proteinsi

Entry informationi

Entry nameiACKA_BACSK
AccessioniPrimary (citable) accession number: Q5WED5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome