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Q5WE05

- SYL_BACSK

UniProt

Q5WE05 - SYL_BACSK

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Protein
Leucine--tRNA ligase
Gene
leuS, ABC2871
Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-2952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:ABC2871
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligaseUniRule annotation
PRO_0000151972Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2871.

Structurei

3D structure databases

ProteinModelPortaliQ5WE05.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi574 – 5785"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WE05-1 [UniParc]FASTAAdd to Basket

« Hide

MSFSHQEIEK KWQAFWEENK TFKTDEQAEG PHFYALDMFP YPSGAGLHVG    50
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGKHPATFT 100
KQNIDTFKRQ IKELGFSYDW DREISTTDPH YYKWTQWIFL KLYEKGLAYI 150
DEVAVNWCPA LGTVLANEEI VDGVSERGGH PVERRPMKQW VLRITAYAER 200
LLEDLEELEW PESLKDMQRN WIGKSEGAEV TFKINEHSVN VFTTRPDTLF 250
GATYMVLAPE HKLVTEITTD EQKEAVEAYQ KQVALKSDIE RTDLAKEKTG 300
AFTGAYAINP VNGEKIPVWI ADYVLISYGT GAVMAVPAHD ERDFEFANAF 350
GLPIKEVVAG GDVSKAAYTG DGEHVNSDFL NGLNKQEAVE KMIVWLEENG 400
AGQRKVTYRL RDWLFSRQRY WGEPIPIIHW EDGSMSALDE SELPLVLPDL 450
EEIKPSGTGE SPLANAKDWL EVVDPKTGMR GRRETNTMPQ WAGSCWYYLR 500
YIDPTNDEAL ADPEKLKNWL PVDTYIGGAE HAVLHLLYAR FWHKFLYDIG 550
VVPTKEPFQK VFNQGMILGE NNEKMSKSKG NVVNPDEIIA SHGADTLRLY 600
EMFMGPLDAS VAWSTNGLDG SRRFLERVWR LIVNEETGKL NSNVKDVEGN 650
EAFVRTYHQT VKKVTEDFAE LRFNTGISQL MVFVNEGNKQ EVLPKALIEG 700
FVKLLSPVAP HIAEELWEKL GHTDTITYEA WPTYDESLLV ENEVEVVVQM 750
NGKVKTKLVI NKGASKEEME AAALADEKVQ AAIGEKTIRK VIAVPGKLVN 800
IVVG 804
Length:804
Mass (Da):91,100
Last modified:November 23, 2004 - v1
Checksum:iD97D7DA775C5AB79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65405.1.
RefSeqiYP_176366.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD65405; BAD65405; ABC2871.
GeneIDi3204060.
KEGGibcl:ABC2871.
PATRICi18925428. VBIBacCla58185_3064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65405.1 .
RefSeqi YP_176366.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WE05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC2871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD65405 ; BAD65405 ; ABC2871 .
GeneIDi 3204060.
KEGGi bcl:ABC2871.
PATRICi 18925428. VBIBacCla58185_3064.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-2952-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiSYL_BACSK
AccessioniPrimary (citable) accession number: Q5WE05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi