Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5WE05

- SYL_BACSK

UniProt

Q5WE05 - SYL_BACSK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei577 – 5771ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-2952-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ABC2871
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligasePRO_0000151972Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2871.

Structurei

3D structure databases

ProteinModelPortaliQ5WE05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi574 – 5785"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WE05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFSHQEIEK KWQAFWEENK TFKTDEQAEG PHFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGKHPATFT
110 120 130 140 150
KQNIDTFKRQ IKELGFSYDW DREISTTDPH YYKWTQWIFL KLYEKGLAYI
160 170 180 190 200
DEVAVNWCPA LGTVLANEEI VDGVSERGGH PVERRPMKQW VLRITAYAER
210 220 230 240 250
LLEDLEELEW PESLKDMQRN WIGKSEGAEV TFKINEHSVN VFTTRPDTLF
260 270 280 290 300
GATYMVLAPE HKLVTEITTD EQKEAVEAYQ KQVALKSDIE RTDLAKEKTG
310 320 330 340 350
AFTGAYAINP VNGEKIPVWI ADYVLISYGT GAVMAVPAHD ERDFEFANAF
360 370 380 390 400
GLPIKEVVAG GDVSKAAYTG DGEHVNSDFL NGLNKQEAVE KMIVWLEENG
410 420 430 440 450
AGQRKVTYRL RDWLFSRQRY WGEPIPIIHW EDGSMSALDE SELPLVLPDL
460 470 480 490 500
EEIKPSGTGE SPLANAKDWL EVVDPKTGMR GRRETNTMPQ WAGSCWYYLR
510 520 530 540 550
YIDPTNDEAL ADPEKLKNWL PVDTYIGGAE HAVLHLLYAR FWHKFLYDIG
560 570 580 590 600
VVPTKEPFQK VFNQGMILGE NNEKMSKSKG NVVNPDEIIA SHGADTLRLY
610 620 630 640 650
EMFMGPLDAS VAWSTNGLDG SRRFLERVWR LIVNEETGKL NSNVKDVEGN
660 670 680 690 700
EAFVRTYHQT VKKVTEDFAE LRFNTGISQL MVFVNEGNKQ EVLPKALIEG
710 720 730 740 750
FVKLLSPVAP HIAEELWEKL GHTDTITYEA WPTYDESLLV ENEVEVVVQM
760 770 780 790 800
NGKVKTKLVI NKGASKEEME AAALADEKVQ AAIGEKTIRK VIAVPGKLVN

IVVG
Length:804
Mass (Da):91,100
Last modified:November 23, 2004 - v1
Checksum:iD97D7DA775C5AB79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD65405.1.
RefSeqiYP_176366.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD65405; BAD65405; ABC2871.
GeneIDi3204060.
KEGGibcl:ABC2871.
PATRICi18925428. VBIBacCla58185_3064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA. Translation: BAD65405.1 .
RefSeqi YP_176366.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WE05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC2871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD65405 ; BAD65405 ; ABC2871 .
GeneIDi 3204060.
KEGGi bcl:ABC2871.
PATRICi 18925428. VBIBacCla58185_3064.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-2952-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiSYL_BACSK
AccessioniPrimary (citable) accession number: Q5WE05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3