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Q5WE05

- SYL_BACSK

UniProt

Q5WE05 - SYL_BACSK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei577 – 5771ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCLA66692:GHMP-2952-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:ABC2871
    OrganismiBacillus clausii (strain KSM-K16)
    Taxonomic identifieri66692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001168: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 804804Leucine--tRNA ligasePRO_0000151972Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi66692.ABC2871.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WE05.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi574 – 5785"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5WE05-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFSHQEIEK KWQAFWEENK TFKTDEQAEG PHFYALDMFP YPSGAGLHVG    50
    HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGKHPATFT 100
    KQNIDTFKRQ IKELGFSYDW DREISTTDPH YYKWTQWIFL KLYEKGLAYI 150
    DEVAVNWCPA LGTVLANEEI VDGVSERGGH PVERRPMKQW VLRITAYAER 200
    LLEDLEELEW PESLKDMQRN WIGKSEGAEV TFKINEHSVN VFTTRPDTLF 250
    GATYMVLAPE HKLVTEITTD EQKEAVEAYQ KQVALKSDIE RTDLAKEKTG 300
    AFTGAYAINP VNGEKIPVWI ADYVLISYGT GAVMAVPAHD ERDFEFANAF 350
    GLPIKEVVAG GDVSKAAYTG DGEHVNSDFL NGLNKQEAVE KMIVWLEENG 400
    AGQRKVTYRL RDWLFSRQRY WGEPIPIIHW EDGSMSALDE SELPLVLPDL 450
    EEIKPSGTGE SPLANAKDWL EVVDPKTGMR GRRETNTMPQ WAGSCWYYLR 500
    YIDPTNDEAL ADPEKLKNWL PVDTYIGGAE HAVLHLLYAR FWHKFLYDIG 550
    VVPTKEPFQK VFNQGMILGE NNEKMSKSKG NVVNPDEIIA SHGADTLRLY 600
    EMFMGPLDAS VAWSTNGLDG SRRFLERVWR LIVNEETGKL NSNVKDVEGN 650
    EAFVRTYHQT VKKVTEDFAE LRFNTGISQL MVFVNEGNKQ EVLPKALIEG 700
    FVKLLSPVAP HIAEELWEKL GHTDTITYEA WPTYDESLLV ENEVEVVVQM 750
    NGKVKTKLVI NKGASKEEME AAALADEKVQ AAIGEKTIRK VIAVPGKLVN 800
    IVVG 804
    Length:804
    Mass (Da):91,100
    Last modified:November 23, 2004 - v1
    Checksum:iD97D7DA775C5AB79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD65405.1.
    RefSeqiYP_176366.1. NC_006582.1.

    Genome annotation databases

    EnsemblBacteriaiBAD65405; BAD65405; ABC2871.
    GeneIDi3204060.
    KEGGibcl:ABC2871.
    PATRICi18925428. VBIBacCla58185_3064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD65405.1 .
    RefSeqi YP_176366.1. NC_006582.1.

    3D structure databases

    ProteinModelPortali Q5WE05.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66692.ABC2871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD65405 ; BAD65405 ; ABC2871 .
    GeneIDi 3204060.
    KEGGi bcl:ABC2871.
    PATRICi 18925428. VBIBacCla58185_3064.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BCLA66692:GHMP-2952-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
      Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KSM-K16.

    Entry informationi

    Entry nameiSYL_BACSK
    AccessioniPrimary (citable) accession number: Q5WE05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3