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Q5WDX0 (G6PI_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:ABC2906
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_0000180588

Sites

Active site2901Proton donor By similarity
Active site3111 By similarity
Active site4251 By similarity

Amino acid modifications

Modified residue381Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5WDX0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 229B1F4D872B388F

FASTA45150,388
        10         20         30         40         50         60 
MAHIQFDYSK ALSFFGEHEV AYMREAVRAA HKALHEKTGQ GNDFLGWIDL PVDYDKEEFA 

        70         80         90        100        110        120 
RIQKAAEKIR HDSDVLLVVG IGGSYLGARA AIEALNHSFF NQLPKEKRNA PQVIFVGQNI 

       130        140        150        160        170        180 
SSTYLSDVLD LLDGKDVSVN VISKSGTTTE PAIAFRVFRD YLEKKYGKEE ARKRIYATTD 

       190        200        210        220        230        240 
KERGALKTLA NEEGYESFVI PDDVGGRFSV LTAVGLLPIA VSGLAIEDMM KGAADAREAF 

       250        260        270        280        290        300 
STGELSENAA YQYAAIRNIL YNKGKTIELL VNYEPHLHYV SEWWKQLFGE SEGKDQKGIY 

       310        320        330        340        350        360 
PASVDFSTDL HSMGQYVQDG RRNLFETVLH VEAVDKHITI EEAESDLDGL NYLAGKTMDF 

       370        380        390        400        410        420 
VNKQAFKGTM LAHTDGNVPN LVVSIPKLDE YSFGYLVYFF EKAVAMSGYL LGVNPFDQPG 

       430        440        450 
VEAYKKNMFA LLGKPGFEEE KNKLESRLTD N

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References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD65440.1.
RefSeqYP_176401.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WDX0.
SMRQ5WDX0. Positions 4-448.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WDX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000046178; EBBACP00000044939; EBBACG00000046169.
GeneID3202099.
GenomeReviewsGene locus ABC2906 in contig AP006627_GR.
KEGGbcl:ABC2906.
NMPDRfig|66692.3.peg.2795.
PATRIC18925506. VBIBacCla58185_3102.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
GeneTreeEBGT00050000001561.
HOGENOMHBG615843.
OMAGQGNDFL.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycBCLA66692:ABC2906-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_BACSK
AccessionPrimary (citable) accession number: Q5WDX0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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