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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. 6-phosphofructokinase (ABC3502), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Proton donorUniRule annotation1
Active sitei311UniRule annotation1
Active sitei425UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-3074-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:ABC2906
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805881 – 451Glucose-6-phosphate isomeraseAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphothreonineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5WDX0

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC2906

Structurei

3D structure databases

ProteinModelPortaliQ5WDX0
SMRiQ5WDX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiSFIIPDD
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WDX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHIQFDYSK ALSFFGEHEV AYMREAVRAA HKALHEKTGQ GNDFLGWIDL
60 70 80 90 100
PVDYDKEEFA RIQKAAEKIR HDSDVLLVVG IGGSYLGARA AIEALNHSFF
110 120 130 140 150
NQLPKEKRNA PQVIFVGQNI SSTYLSDVLD LLDGKDVSVN VISKSGTTTE
160 170 180 190 200
PAIAFRVFRD YLEKKYGKEE ARKRIYATTD KERGALKTLA NEEGYESFVI
210 220 230 240 250
PDDVGGRFSV LTAVGLLPIA VSGLAIEDMM KGAADAREAF STGELSENAA
260 270 280 290 300
YQYAAIRNIL YNKGKTIELL VNYEPHLHYV SEWWKQLFGE SEGKDQKGIY
310 320 330 340 350
PASVDFSTDL HSMGQYVQDG RRNLFETVLH VEAVDKHITI EEAESDLDGL
360 370 380 390 400
NYLAGKTMDF VNKQAFKGTM LAHTDGNVPN LVVSIPKLDE YSFGYLVYFF
410 420 430 440 450
EKAVAMSGYL LGVNPFDQPG VEAYKKNMFA LLGKPGFEEE KNKLESRLTD

N
Length:451
Mass (Da):50,388
Last modified:November 23, 2004 - v1
Checksum:i229B1F4D872B388F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD65440.1
RefSeqiWP_011247748.1, NC_006582.1

Genome annotation databases

EnsemblBacteriaiBAD65440; BAD65440; ABC2906
GeneIDi34045921
KEGGibcl:ABC2906

Similar proteinsi

Entry informationi

Entry nameiG6PI_BACSK
AccessioniPrimary (citable) accession number: Q5WDX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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