Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5WDW4 (THIM_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:ABC2912
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000336545

Sites

Binding site361Substrate; via amide nitrogen By similarity
Binding site1121ATP By similarity
Binding site1571ATP By similarity
Binding site1841Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5WDW4 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 89D2AD602E079081

FASTA26026,970
        10         20         30         40         50         60 
MELVRQNNPL IHCMTNDVVM NFTANGLLAI GASPVMAFSA AETEDMASVA DALLLNIGTP 

        70         80         90        100        110        120 
SNEGVDSMVL AGKAANRAGK PVIFDPVGVG ATPFRNEISK RILNEVDVAV VRGNAGEIAA 

       130        140        150        160        170        180 
LLGQAGTVKG VDGKINADVK ELCLQAAKAL RTVVVVTGEV DAVSNGEQLV AVANGHEWLT 

       190        200        210        220        230        240 
KVVGTGCLLG GVIAAYAAVQ PNSLVDAAVE ALAFYGVCAE QAYEQTKKEG IGSFQQTFLN 

       250        260 
ELGNMTDEKA AALKRVEQIC 

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006627 Genomic DNA. Translation: BAD65446.1.
RefSeqYP_176407.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WDW4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING66692.ABC2912.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD65446; BAD65446; ABC2912.
GeneID3203415.
KEGGbcl:ABC2912.
PATRIC18925518. VBIBacCla58185_3108.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycBCLA66692:GHMP-2994-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_BACSK
AccessionPrimary (citable) accession number: Q5WDW4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways