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Q5WDV0 (MTLD_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:ABC2926
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000011796

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5WDV0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 27BC7CAFEA595416

FASTA37441,332
        10         20         30         40         50         60 
MKAVHFGAGN IGRGFIGALL VDAGYEVTFV DVNEKIIDAL NERNEYKVTV AGERKETETV 

        70         80         90        100        110        120 
TNVRGINSKT NEKEAIDAIA EADIVTTAVG PTVLPYIAKT IAQGLKQRTA SKPVNMIACE 

       130        140        150        160        170        180 
NAIRATSQLK KDVLSHLSEE ETTALLKDAG FADAAVDRIV PNVQSDDILH VTVEPFFEWV 

       190        200        210        220        230        240 
VEKPALKGDA VQLGKAVLVE DLAPYIERKL FTVNTGHAVA AYVGYRKGKK TIKEALADDY 

       250        260        270        280        290        300 
IKHRVRGALN ETKAMLVEEY QFDAEAHEDY IDKILLRFQN PHLEDLVERV GRGPIRKLGP 

       310        320        330        340        350        360 
ADRLVKPAKY LAEKGLHPES LAETIFDALH FYAEGDPESE ELRALVDEKG YVDAFCEISK 

       370 
LEKDHPLVEI VAKE

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References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD65460.1.
RefSeqYP_176421.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WDV0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WDV0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000048744; EBBACP00000047505; EBBACG00000048735.
GeneID3204485.
GenomeReviewsGene locus ABC2926 in contig AP006627_GR.
KEGGbcl:ABC2926.
NMPDRfig|66692.3.peg.2814.
PATRIC18925546. VBIBacCla58185_3122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
GeneTreeEBGT00050000001216.
HOGENOMHBG568825.
OMAFANTAVD.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycBCLA66692:ABC2926-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_BACSK
AccessionPrimary (citable) accession number: Q5WDV0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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