Reviewed, UniProtKB/Swiss-Prot Q5WDV0 (MTLD_BACSK)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	ABC2926

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011796
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5WDV0-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 27BC7CAFEA595416	FASTA	374	41,332
	10 20 30 40 50 60 MKAVHFGAGN IGRGFIGALL VDAGYEVTFV DVNEKIIDAL NERNEYKVTV AGERKETETV 70 80 90 100 110 120 TNVRGINSKT NEKEAIDAIA EADIVTTAVG PTVLPYIAKT IAQGLKQRTA SKPVNMIACE 130 140 150 160 170 180 NAIRATSQLK KDVLSHLSEE ETTALLKDAG FADAAVDRIV PNVQSDDILH VTVEPFFEWV 190 200 210 220 230 240 VEKPALKGDA VQLGKAVLVE DLAPYIERKL FTVNTGHAVA AYVGYRKGKK TIKEALADDY 250 260 270 280 290 300 IKHRVRGALN ETKAMLVEEY QFDAEAHEDY IDKILLRFQN PHLEDLVERV GRGPIRKLGP 310 320 330 340 350 360 ADRLVKPAKY LAEKGLHPES LAETIFDALH FYAEGDPESE ELRALVDEKG YVDAFCEISK 370 LEKDHPLVEI VAKE

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD65460.1.
RefSeq	YP_176421.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WDV0.
Genome annotation databases
GeneID	3204485.
GenomeReviews	Gene locus ABC2926 in contig AP006627_GR.
KEGG	bcl:ABC2926.
NMPDR	fig|66692.3.peg.2814.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WDV0.
OMA	VDRIVPN.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC2926-MON.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_BACSK

Accession

Primary (citable) accession number: Q5WDV0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)