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Q5WDT6 (KHSE_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:ABC2940
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesBacillaceaeBacillus

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Homoserine kinase HAMAP MF_00384
PRO_0000156553

Regions

Nucleotide binding84 – 9411ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5WDT6 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 9546BD9B1A66C60B

FASTA29731,324
        10         20         30         40         50         60 
MAFSITVPAS TANLGPGFDS IGLALNRYLH LEVEQASKWS FICSSPGLEN IGTDNLVTKA 

        70         80         90        100        110        120 
ATFASKEWGK VLPPCQVVMK NDIPLSKGFG SSAAAIVAGI ELAASVCGQF ASKAEKARLA 

       130        140        150        160        170        180 
SLWEGHPDNV AASIYGGLVI GTHSEESTEI LHVEAPNIDL VALIPSKTLA TKKARAVLPD 

       190        200        210        220        230        240 
MLSYKEAVQA SSVANVLAAA LVKQDWELVG KMMLADRFHQ PYRQQLIPHL PDVCAYAQAD 

       250        260        270        280        290 
EDAYGAALSG AGPIILCLVK EGKGEAFASR LHKQFPACRA EVMRPAVQGS AVSIAQA 

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006627 Genomic DNA. Translation: BAD65474.1.
RefSeqYP_176435.1. NC_006582.1.

3D structure databases

ProteinModelPortalQ5WDT6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WDT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000049828; EBBACP00000048589; EBBACG00000049819.
GeneID3203418.
GenomeReviewsGene locus ABC2940 in contig AP006627_GR.
KEGGbcl:ABC2940.
NMPDRfig|66692.3.peg.2828.
PATRIC18925578. VBIBacCla58185_3138.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
GeneTreeEBGT00050000000874.
HOGENOMHBG646290.
OMADRLHQPY.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycBCLA66692:ABC2940-MONOMER.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_BACSK
AccessionPrimary (citable) accession number: Q5WDT6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families