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Q5WDK7 (TPIS_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Triosephosphate isomerase
Short name=TIM
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase
Gene names
Name:tpiA
Ordered Locus Names:ABC3019
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP MF_00147_B

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00147_B

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP MF_00147_B

Subunit structure

Homodimer By similarity. HAMAP MF_00147_B

Subcellular location

Cytoplasm By similarity HAMAP MF_00147_B.

Sequence similarities

Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Triosephosphate isomerase HAMAP MF_00147_B
PRO_0000307427

Sites

Active site951Electrophile By similarity
Active site1671Proton acceptor By similarity
Binding site91Substrate By similarity
Binding site111Substrate By similarity

Amino acid modifications

Modified residue2131Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5WDK7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: EEF230629F5E0568

FASTA25126,868
        10         20         30         40         50         60 
MRKPIIAGNW KMNKTIGEAV DFVEAVKANV PAQATVDSVV CAPALFLDRL LQAVKGTELK 

        70         80         90        100        110        120 
IGAQTMHFED NGAFTGEISP KALSDMGVHY VIIGHSERRE MFAETDETVN KKVHAAFAHH 

       130        140        150        160        170        180 
LVPIMCCGET AEEREAGKME AVVKEQVENG LAGLSEEQVK QTVIAYEPIW AIGTGKSATE 

       190        200        210        220        230        240 
KDANEACAYV RQTVAANFSE EAAEAIRIQY GGSVKPGNIK DYMAQPDIDG ALVGGASLDA 

       250 
DSFLELVGAA K

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006627 Genomic DNA. Translation: BAD65553.1.
RefSeqYP_176514.1. NC_006582.1.

3D structure databases

HSSPHSSP built from PDB template 2BTM based on UniProtKB P00943.
ProteinModelPortalQ5WDK7.
SMRQ5WDK7. Positions 2-251.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5WDK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000049439; EBBACP00000048200; EBBACG00000049430.
GeneID3203430.
GenomeReviewsGene locus ABC3019 in contig AP006627_GR.
KEGGbcl:ABC3019.
NMPDRfig|66692.3.peg.2908.
PATRIC18925744. VBIBacCla58185_3221.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0149.
GeneTreeEBGT00050000002739.
HOGENOMHBG708281.
OMAANTVIAY.

Enzyme and pathway databases

BioCycBCLA66692:ABC3019-MONOMER.

Family and domain databases

HAMAPMF_00147_B. TIM_B.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01803.
PANTHERPTHR21139. Triophos_ismrse. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. Triophos_ismrse. 1 hit.
TIGRFAMsTIGR00419. Tim. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPIS_BACSK
AccessionPrimary (citable) accession number: Q5WDK7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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