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Reviewed, UniProtKB/Swiss-Prot Q5WDH8 (HISX2_BACSK)

Last modified June 16, 2009. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase 2
      Short name=HDH 2
    EC=1.1.1.23
Gene names
Name: hisD2
Ordered Locus Names: ABC3048
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD+ = L-histidine + 2 NADH. HAMAP MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 425425Histidinol dehydrogenase 2 HAMAP MF_01024
PRO_0000135725

Sites

Active site3211Proton acceptor By similarity
Active site3221Proton acceptor By similarity
Metal binding2531Zinc By similarity
Metal binding2561Zinc By similarity
Metal binding3551Zinc By similarity
Metal binding4141Zinc By similarity
Binding site1231NAD By similarity
Binding site1851NAD By similarity
Binding site2081NAD By similarity
Binding site2311Substrate By similarity
Binding site2531Substrate By similarity
Binding site2561Substrate By similarity
Binding site3221Substrate By similarity
Binding site3551Substrate By similarity
Binding site4091Substrate By similarity
Binding site4141Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q5WDH8-1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 071216AAFCD82413

FASTA42544,989
        10         20         30         40         50         60 
MKIIELKEGE AVSLKRSGLH GSEAEIATVN TIIETVKKEG DQALVDYTQQ FDGVELTDLC 

        70         80         90        100        110        120 
VTKAELDNAY RHIDQPVLAA IRQAIANVRA FHEQQKAKSW FQTAPDGTIL GQRVTPLDAV 

       130        140        150        160        170        180 
GVYVPGGKAA YPSSIIMNVV PAQVAGVKDI SMVSPSGKNG TLPPAVLATA AELGVHTIYK 

       190        200        210        220        230        240 
LGGAQAVAAL AYGTETVRPV DKITGPGNKY VALAKRAVFG DVAIDMIAGP SEICVLADEK 

       250        260        270        280        290        300 
ANPAYVAADL LSQAEHDEDA TAVLVTPSRK LAEAVQQETA RQLATLPRKE IAGRALEQFG 

       310        320        330        340        350        360 
ALYVTASLAQ AIEVVNQLAP EHLEIATEEP LALLGRVKHA GAIFLGSYSA EPVGDYFAGP 

       370        380        390        400        410        420 
NHVLPTNGTA RFASPLSVDD FVKKSSIISY SKTALAENGK AITELARLEG LEAHARAIDI 


RLEDM

« Hide

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References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AP006627 Genomic DNA. Translation: BAD65582.1.
RefSeqYP_176543.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3204579.
GenomeReviewsGene locus ABC3048 in contig AP006627_GR.
KEGGbcl:ABC3048.
NMPDRfig|66692.3.peg.2958.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ5WDH8.
OMAQ5WDH8. LGVETFM.

Enzyme and pathway databases

BioCycBCLA66692:ABC3048-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH_prok-type.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX2_BACSK
AccessionPrimary (citable) accession number: Q5WDH8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: June 16, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents