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Q5WDH8

- HISX2_BACSK

UniProt

Q5WDH8 - HISX2_BACSK

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Protein

Histidinol dehydrogenase 2

Gene
hisD2, ABC3048
Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NAD By similarity
Binding sitei185 – 1851NAD By similarity
Binding sitei208 – 2081NAD By similarity
Binding sitei231 – 2311Substrate By similarity
Metal bindingi253 – 2531Zinc By similarity
Binding sitei253 – 2531Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Active sitei321 – 3211Proton acceptor By similarity
Active sitei322 – 3221Proton acceptor By similarity
Binding sitei322 – 3221Substrate By similarity
Metal bindingi355 – 3551Zinc By similarity
Binding sitei355 – 3551Substrate By similarity
Binding sitei409 – 4091Substrate By similarity
Metal bindingi414 – 4141Zinc By similarity
Binding sitei414 – 4141Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-3130-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:ABC3048
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425Histidinol dehydrogenase 2UniRule annotationPRO_0000135725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi66692.ABC3048.

Structurei

3D structure databases

ProteinModelPortaliQ5WDH8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5WDH8-1 [UniParc]FASTAAdd to Basket

« Hide

MKIIELKEGE AVSLKRSGLH GSEAEIATVN TIIETVKKEG DQALVDYTQQ    50
FDGVELTDLC VTKAELDNAY RHIDQPVLAA IRQAIANVRA FHEQQKAKSW 100
FQTAPDGTIL GQRVTPLDAV GVYVPGGKAA YPSSIIMNVV PAQVAGVKDI 150
SMVSPSGKNG TLPPAVLATA AELGVHTIYK LGGAQAVAAL AYGTETVRPV 200
DKITGPGNKY VALAKRAVFG DVAIDMIAGP SEICVLADEK ANPAYVAADL 250
LSQAEHDEDA TAVLVTPSRK LAEAVQQETA RQLATLPRKE IAGRALEQFG 300
ALYVTASLAQ AIEVVNQLAP EHLEIATEEP LALLGRVKHA GAIFLGSYSA 350
EPVGDYFAGP NHVLPTNGTA RFASPLSVDD FVKKSSIISY SKTALAENGK 400
AITELARLEG LEAHARAIDI RLEDM 425
Length:425
Mass (Da):44,989
Last modified:November 23, 2004 - v1
Checksum:i071216AAFCD82413
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65582.1.
RefSeqiYP_176543.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD65582; BAD65582; ABC3048.
GeneIDi3204579.
KEGGibcl:ABC3048.
PATRICi18925810. VBIBacCla58185_3254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65582.1 .
RefSeqi YP_176543.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WDH8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC3048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD65582 ; BAD65582 ; ABC3048 .
GeneIDi 3204579.
KEGGi bcl:ABC3048.
PATRICi 18925810. VBIBacCla58185_3254.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BCLA66692:GHMP-3130-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiHISX2_BACSK
AccessioniPrimary (citable) accession number: Q5WDH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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