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Q5WDH8

- HISX2_BACSK

UniProt

Q5WDH8 - HISX2_BACSK

Protein

Histidinol dehydrogenase 2

Gene

hisD2

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231NADUniRule annotation
    Binding sitei185 – 1851NADUniRule annotation
    Binding sitei208 – 2081NADUniRule annotation
    Binding sitei231 – 2311SubstrateUniRule annotation
    Metal bindingi253 – 2531ZincUniRule annotation
    Binding sitei253 – 2531SubstrateUniRule annotation
    Metal bindingi256 – 2561ZincUniRule annotation
    Binding sitei256 – 2561SubstrateUniRule annotation
    Active sitei321 – 3211Proton acceptorUniRule annotation
    Active sitei322 – 3221Proton acceptorUniRule annotation
    Binding sitei322 – 3221SubstrateUniRule annotation
    Metal bindingi355 – 3551ZincUniRule annotation
    Binding sitei355 – 3551SubstrateUniRule annotation
    Binding sitei409 – 4091SubstrateUniRule annotation
    Metal bindingi414 – 4141ZincUniRule annotation
    Binding sitei414 – 4141SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciBCLA66692:GHMP-3130-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase 2UniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDH 2UniRule annotation
    Gene namesi
    Name:hisD2UniRule annotation
    Ordered Locus Names:ABC3048
    OrganismiBacillus clausii (strain KSM-K16)
    Taxonomic identifieri66692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 425425Histidinol dehydrogenase 2PRO_0000135725Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi66692.ABC3048.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WDH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5WDH8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIIELKEGE AVSLKRSGLH GSEAEIATVN TIIETVKKEG DQALVDYTQQ    50
    FDGVELTDLC VTKAELDNAY RHIDQPVLAA IRQAIANVRA FHEQQKAKSW 100
    FQTAPDGTIL GQRVTPLDAV GVYVPGGKAA YPSSIIMNVV PAQVAGVKDI 150
    SMVSPSGKNG TLPPAVLATA AELGVHTIYK LGGAQAVAAL AYGTETVRPV 200
    DKITGPGNKY VALAKRAVFG DVAIDMIAGP SEICVLADEK ANPAYVAADL 250
    LSQAEHDEDA TAVLVTPSRK LAEAVQQETA RQLATLPRKE IAGRALEQFG 300
    ALYVTASLAQ AIEVVNQLAP EHLEIATEEP LALLGRVKHA GAIFLGSYSA 350
    EPVGDYFAGP NHVLPTNGTA RFASPLSVDD FVKKSSIISY SKTALAENGK 400
    AITELARLEG LEAHARAIDI RLEDM 425
    Length:425
    Mass (Da):44,989
    Last modified:November 23, 2004 - v1
    Checksum:i071216AAFCD82413
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD65582.1.
    RefSeqiYP_176543.1. NC_006582.1.

    Genome annotation databases

    EnsemblBacteriaiBAD65582; BAD65582; ABC3048.
    GeneIDi3204579.
    KEGGibcl:ABC3048.
    PATRICi18925810. VBIBacCla58185_3254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD65582.1 .
    RefSeqi YP_176543.1. NC_006582.1.

    3D structure databases

    ProteinModelPortali Q5WDH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66692.ABC3048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD65582 ; BAD65582 ; ABC3048 .
    GeneIDi 3204579.
    KEGGi bcl:ABC3048.
    PATRICi 18925810. VBIBacCla58185_3254.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci BCLA66692:GHMP-3130-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
      Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KSM-K16.

    Entry informationi

    Entry nameiHISX2_BACSK
    AccessioniPrimary (citable) accession number: Q5WDH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3