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Q5WCX5 (UPPP2_BACSK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Ordered Locus Names:ABC3251
OrganismBacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]
Taxonomic identifier66692 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 275275Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006
PRO_0000151108

Regions

Transmembrane48 – 6821Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane195 – 21521Helical; Potential
Transmembrane223 – 24321Helical; Potential
Transmembrane254 – 27421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5WCX5 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: EEF1F39EF55AFE48

FASTA27529,930
        10         20         30         40         50         60 
MDVWEWVVAA ILGLVEGLTE YAPVSSTGHM IIVDDLWLKS SELVGSQNAY VFKIVIQLGS 

        70         80         90        100        110        120 
ILAVALLFKD RLLQLAGFKK QAATQSEGRG LTLGKVAVGL LPAAVLGLLF EDKMESIFHV 

       130        140        150        160        170        180 
RTVAFALIAG AFLMIAADFI NKRNNKKKQQ VDDISYKQAL AIGLFQCLAL WPGFSRSGST 

       190        200        210        220        230        240 
ISGGVMLGLT HRAAANFTFI MAIPIMVGAS ALSLIKNWDA LDISLLPFYA TGFISAFLVS 

       250        260        270 
LVVVRFFLKL INKIKLVPFA LYRIALGLLL LFLFS 

« Hide

References

[1]"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KSM-K16.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006627 Genomic DNA. Translation: BAD65785.1.
RefSeqYP_176746.1. NC_006582.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING66692.ABC3251.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD65785; BAD65785; ABC3251.
GeneID3200742.
KEGGbcl:ABC3251.
PATRIC18926226. VBIBacCla58185_3462.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAMILVEEF.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycBCLA66692:GHMP-3333-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_BACSK
AccessionPrimary (citable) accession number: Q5WCX5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families