Q5WCX5 (UPPP2_BACSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2

Gene names

Name:	uppP2
Ordered Locus Names:	ABC3251

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus clausii

Protein attributes

Sequence length	275 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 275	275	Undecaprenyl-diphosphatase 2 HAMAP-Rule MF_01006		PRO_0000151108
Regions
	Transmembrane	48 – 68	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	117 – 137	21	Helical; Potential
	Transmembrane	154 – 174	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	223 – 243	21	Helical; Potential
	Transmembrane	254 – 274	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5WCX5 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: EEF1F39EF55AFE48	FASTA	275	29,930
	10 20 30 40 50 60 MDVWEWVVAA ILGLVEGLTE YAPVSSTGHM IIVDDLWLKS SELVGSQNAY VFKIVIQLGS 70 80 90 100 110 120 ILAVALLFKD RLLQLAGFKK QAATQSEGRG LTLGKVAVGL LPAAVLGLLF EDKMESIFHV 130 140 150 160 170 180 RTVAFALIAG AFLMIAADFI NKRNNKKKQQ VDDISYKQAL AIGLFQCLAL WPGFSRSGST 190 200 210 220 230 240 ISGGVMLGLT HRAAANFTFI MAIPIMVGAS ALSLIKNWDA LDISLLPFYA TGFISAFLVS 250 260 270 LVVVRFFLKL INKIKLVPFA LYRIALGLLL LFLFS

References

[1]

"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KSM-K16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006627 Genomic DNA. Translation: BAD65785.1.
RefSeq	YP_176746.1. NC_006582.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	66692.ABC3251.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD65785; BAD65785; ABC3251.
GeneID	3200742.
KEGG	bcl:ABC3251.
PATRIC	18926226. VBIBacCla58185_3462.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218356.
KO	K06153.
OMA	RWLLRYI.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	BCLA66692:GHMP-3243-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP2_BACSK

Accession

Primary (citable) accession number: Q5WCX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program