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Q5WCF2

- HDOX_BACSK

UniProt

Q5WCF2 - HDOX_BACSK

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Protein
Heme-degrading monooxygenase
Gene
isdG, ABC3425
Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron By similarity.UniRule annotation

Catalytic activityi

Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Iron By similarity
Sitei66 – 661Transition state stabilizer By similarity
Metal bindingi76 – 761Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: UniProtKB-HAMAP
  2. heme oxygenase (decyclizing) activity Source: UniProtKB-HAMAP
  3. iron ion binding Source: UniProtKB-HAMAP
  4. monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  1. heme catabolic process Source: UniProtKB-HAMAP
  2. iron assimilation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-3507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-degrading monooxygenase (EC:1.14.99.3)
Alternative name(s):
Heme oxygenase
Iron-regulated surface determinant
Iron-responsive surface determinant
Gene namesi
Name:isdG
Ordered Locus Names:ABC3425
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 107107Heme-degrading monooxygenaseUniRule annotation
PRO_0000270074Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC3425.

Structurei

3D structure databases

ProteinModelPortaliQ5WCF2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2329.
HOGENOMiHOG000008026.
KOiK07145.
OMAiFRESHSH.
OrthoDBiEOG6GTZMS.

Family and domain databases

HAMAPiMF_01272. Heme_degrading_monooxygenase.
InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WCF2-1 [UniParc]FASTAAdd to Basket

« Hide

MVIVANKTLI RKGEGHKLVK RFDKIGKIEM QKGFLGLEVL VNAKEKEVDE    50
VTISTRWETK ADFHAWTKSE AFREAHSGRN ARPDYILGNE IEFYDVEVVR 100
MPIAQAQ 107
Length:107
Mass (Da):12,302
Last modified:November 23, 2004 - v1
Checksum:i31ED9218A7A4B6D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65958.1.
RefSeqiYP_176919.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD65958; BAD65958; ABC3425.
GeneIDi3202635.
KEGGibcl:ABC3425.
PATRICi18926596. VBIBacCla58185_3646.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD65958.1 .
RefSeqi YP_176919.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WCF2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC3425.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD65958 ; BAD65958 ; ABC3425 .
GeneIDi 3202635.
KEGGi bcl:ABC3425.
PATRICi 18926596. VBIBacCla58185_3646.

Phylogenomic databases

eggNOGi COG2329.
HOGENOMi HOG000008026.
KOi K07145.
OMAi FRESHSH.
OrthoDBi EOG6GTZMS.

Enzyme and pathway databases

BioCyci BCLA66692:GHMP-3507-MONOMER.

Family and domain databases

HAMAPi MF_01272. Heme_degrading_monooxygenase.
InterProi IPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR023953. IsdG.
[Graphical view ]
Pfami PF03992. ABM. 1 hit.
[Graphical view ]
SUPFAMi SSF54909. SSF54909. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiHDOX_BACSK
AccessioniPrimary (citable) accession number: Q5WCF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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