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Q5WBJ6

- ALLB_BACSK

UniProt

Q5WBJ6 - ALLB_BACSK

Protein

Allantoinase

Gene

allB

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Zinc 1UniRule annotation
    Metal bindingi61 – 611Zinc 1UniRule annotation
    Metal bindingi146 – 1461Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi146 – 1461Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi185 – 1851Zinc 2UniRule annotation
    Metal bindingi239 – 2391Zinc 2UniRule annotation
    Metal bindingi312 – 3121Zinc 1UniRule annotation

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-HAMAP
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBCLA66692:GHMP-3813-MONOMER.
    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
    Alternative name(s):
    Allantoin-utilizing enzymeUniRule annotation
    Gene namesi
    Name:allBUniRule annotation
    Synonyms:pucHUniRule annotation
    Ordered Locus Names:ABC3732
    OrganismiBacillus clausii (strain KSM-K16)
    Taxonomic identifieri66692 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001168: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448AllantoinasePRO_0000317669Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei146 – 1461N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi66692.ABC3732.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5WBJ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0044.
    HOGENOMiHOG000219146.
    KOiK01466.
    OMAiCSPWEGH.
    OrthoDBiEOG6KHFW6.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01645. Hydantoinase.
    InterProiIPR017593. Allantoinase.
    IPR013108. Amidohydro_3.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    PfamiPF07969. Amidohydro_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5WBJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDLCITGGR VVLPSGVEET DVGIQAGKIA RIGPINKKEA RCIMNANGQY    50
    VFPGAVDTHV HFSEPGRTEW EGFFTGSRSL AAGGTTTYVE MPLNALPATT 100
    NRANLQRKLE AAKGQNYVDY SFYGGLVPTN LHELADLSAS GVVAFKCFLS 150
    PCGSDIPGDF RNVDLNGLRA GMRLLAEKGQ LLCVHAEDPS MISQLEAKLL 200
    SPVGADAYVA SRPVEAEVKA VCDTLAAARE TGCRIHFVHI SSAAAIEAIE 250
    RAKEEGVDVT VESCPHYFLL SAEELAELGP LAKCQPPLRP KQEQAKLWAC 300
    LLDGQIDWLA SDHSPCTPDL KDGDFLTAWG GISGCQNNID IMFDAAVKRR 350
    GMPPEQLARL IATNPAKRMN LREKGEIAIG KDADFAFVDD RQSYTLTKEQ 400
    LYYKNKHSPY VGRTIGCKVR RVLLRGQTIY TEEKGIIGKP SGELLHIH 448
    Length:448
    Mass (Da):48,711
    Last modified:November 23, 2004 - v1
    Checksum:i903BD489E7C7ACF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD66264.1.
    RefSeqiYP_177225.1. NC_006582.1.

    Genome annotation databases

    EnsemblBacteriaiBAD66264; BAD66264; ABC3732.
    GeneIDi3202800.
    KEGGibcl:ABC3732.
    PATRICi18927260. VBIBacCla58185_3978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006627 Genomic DNA. Translation: BAD66264.1 .
    RefSeqi YP_177225.1. NC_006582.1.

    3D structure databases

    ProteinModelPortali Q5WBJ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 66692.ABC3732.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD66264 ; BAD66264 ; ABC3732 .
    GeneIDi 3202800.
    KEGGi bcl:ABC3732.
    PATRICi 18927260. VBIBacCla58185_3978.

    Phylogenomic databases

    eggNOGi COG0044.
    HOGENOMi HOG000219146.
    KOi K01466.
    OMAi CSPWEGH.
    OrthoDBi EOG6KHFW6.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .
    BioCyci BCLA66692:GHMP-3813-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01645. Hydantoinase.
    InterProi IPR017593. Allantoinase.
    IPR013108. Amidohydro_3.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    Pfami PF07969. Amidohydro_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
      Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KSM-K16.

    Entry informationi

    Entry nameiALLB_BACSK
    AccessioniPrimary (citable) accession number: Q5WBJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3