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Q5WBJ6

- ALLB_BACSK

UniProt

Q5WBJ6 - ALLB_BACSK

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Protein

Allantoinase

Gene

allB

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Zinc 1UniRule annotation
Metal bindingi61 – 611Zinc 1UniRule annotation
Metal bindingi146 – 1461Zinc 1; via carbamate groupUniRule annotation
Metal bindingi146 – 1461Zinc 2; via carbamate groupUniRule annotation
Metal bindingi185 – 1851Zinc 2UniRule annotation
Metal bindingi239 – 2391Zinc 2UniRule annotation
Metal bindingi312 – 3121Zinc 1UniRule annotation

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBCLA66692:GHMP-3813-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
Ordered Locus Names:ABC3732
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001168: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448AllantoinasePRO_0000317669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC3732.

Structurei

3D structure databases

ProteinModelPortaliQ5WBJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiCSPWEGH.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR013108. Amidohydro_3.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamiPF07969. Amidohydro_3. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5WBJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDLCITGGR VVLPSGVEET DVGIQAGKIA RIGPINKKEA RCIMNANGQY
60 70 80 90 100
VFPGAVDTHV HFSEPGRTEW EGFFTGSRSL AAGGTTTYVE MPLNALPATT
110 120 130 140 150
NRANLQRKLE AAKGQNYVDY SFYGGLVPTN LHELADLSAS GVVAFKCFLS
160 170 180 190 200
PCGSDIPGDF RNVDLNGLRA GMRLLAEKGQ LLCVHAEDPS MISQLEAKLL
210 220 230 240 250
SPVGADAYVA SRPVEAEVKA VCDTLAAARE TGCRIHFVHI SSAAAIEAIE
260 270 280 290 300
RAKEEGVDVT VESCPHYFLL SAEELAELGP LAKCQPPLRP KQEQAKLWAC
310 320 330 340 350
LLDGQIDWLA SDHSPCTPDL KDGDFLTAWG GISGCQNNID IMFDAAVKRR
360 370 380 390 400
GMPPEQLARL IATNPAKRMN LREKGEIAIG KDADFAFVDD RQSYTLTKEQ
410 420 430 440
LYYKNKHSPY VGRTIGCKVR RVLLRGQTIY TEEKGIIGKP SGELLHIH
Length:448
Mass (Da):48,711
Last modified:November 23, 2004 - v1
Checksum:i903BD489E7C7ACF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD66264.1.
RefSeqiYP_177225.1. NC_006582.1.

Genome annotation databases

EnsemblBacteriaiBAD66264; BAD66264; ABC3732.
GeneIDi3202800.
KEGGibcl:ABC3732.
PATRICi18927260. VBIBacCla58185_3978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006627 Genomic DNA. Translation: BAD66264.1 .
RefSeqi YP_177225.1. NC_006582.1.

3D structure databases

ProteinModelPortali Q5WBJ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 66692.ABC3732.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD66264 ; BAD66264 ; ABC3732 .
GeneIDi 3202800.
KEGGi bcl:ABC3732.
PATRICi 18927260. VBIBacCla58185_3978.

Phylogenomic databases

eggNOGi COG0044.
HOGENOMi HOG000219146.
KOi K01466.
OMAi CSPWEGH.
OrthoDBi EOG6KHFW6.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .
BioCyci BCLA66692:GHMP-3813-MONOMER.

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
HAMAPi MF_01645. Hydantoinase.
InterProi IPR017593. Allantoinase.
IPR013108. Amidohydro_3.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
Pfami PF07969. Amidohydro_3. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16."
    Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KSM-K16.

Entry informationi

Entry nameiALLB_BACSK
AccessioniPrimary (citable) accession number: Q5WBJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3