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Protein

Allantoinase

Gene

allB

Organism
Bacillus clausii (strain KSM-K16)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoinase (allB)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Zinc 1UniRule annotation1
Metal bindingi61Zinc 1UniRule annotation1
Metal bindingi146Zinc 1; via carbamate groupUniRule annotation1
Metal bindingi146Zinc 2; via carbamate groupUniRule annotation1
Metal bindingi185Zinc 2UniRule annotation1
Metal bindingi239Zinc 2UniRule annotation1
Metal bindingi312Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciBCLA66692:G1G25-3919-MONOMER
UniPathwayiUPA00395; UER00653

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Synonyms:pucHUniRule annotation
Ordered Locus Names:ABC3732
OrganismiBacillus clausii (strain KSM-K16)
Taxonomic identifieri66692 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001168 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176691 – 448AllantoinaseAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146N6-carboxylysineUniRule annotation1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Proteomic databases

PRIDEiQ5WBJ6

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi66692.ABC3732

Structurei

3D structure databases

ProteinModelPortaliQ5WBJ6
SMRiQ5WBJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CD3 Bacteria
COG0044 LUCA
HOGENOMiHOG000219146
KOiK01466
OMAiHFNEPGR
OrthoDBiPOG091H02CH

Family and domain databases

Gene3Di2.30.40.10, 3 hits
HAMAPiMF_01645 Hydantoinase, 1 hit
InterProiView protein in InterPro
IPR017593 Allantoinase
IPR006680 Amidohydro-rel
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR03178 allantoinase, 1 hit

Sequencei

Sequence statusi: Complete.

Q5WBJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDLCITGGR VVLPSGVEET DVGIQAGKIA RIGPINKKEA RCIMNANGQY
60 70 80 90 100
VFPGAVDTHV HFSEPGRTEW EGFFTGSRSL AAGGTTTYVE MPLNALPATT
110 120 130 140 150
NRANLQRKLE AAKGQNYVDY SFYGGLVPTN LHELADLSAS GVVAFKCFLS
160 170 180 190 200
PCGSDIPGDF RNVDLNGLRA GMRLLAEKGQ LLCVHAEDPS MISQLEAKLL
210 220 230 240 250
SPVGADAYVA SRPVEAEVKA VCDTLAAARE TGCRIHFVHI SSAAAIEAIE
260 270 280 290 300
RAKEEGVDVT VESCPHYFLL SAEELAELGP LAKCQPPLRP KQEQAKLWAC
310 320 330 340 350
LLDGQIDWLA SDHSPCTPDL KDGDFLTAWG GISGCQNNID IMFDAAVKRR
360 370 380 390 400
GMPPEQLARL IATNPAKRMN LREKGEIAIG KDADFAFVDD RQSYTLTKEQ
410 420 430 440
LYYKNKHSPY VGRTIGCKVR RVLLRGQTIY TEEKGIIGKP SGELLHIH
Length:448
Mass (Da):48,711
Last modified:November 23, 2004 - v1
Checksum:i903BD489E7C7ACF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006627 Genomic DNA Translation: BAD66264.1
RefSeqiWP_011248568.1, NC_006582.1

Genome annotation databases

EnsemblBacteriaiBAD66264; BAD66264; ABC3732
GeneIDi34044108
KEGGibcl:ABC3732

Similar proteinsi

Entry informationi

Entry nameiALLB_BACSK
AccessioniPrimary (citable) accession number: Q5WBJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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