Reviewed, UniProtKB/Swiss-Prot Q5WB34 (SYR_BACSK)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	ABC3895

Organism

Bacillus clausii (strain KSM-K16) [Complete proteome] [HAMAP]

Taxonomic identifier

66692 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00123
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_0000241982
Regions
	Motif	132 – 142	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q5WB34-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 16141FBCD803792D	FASTA	556	62,498
	10 20 30 40 50 60 MNHMERKKEQ LRVEVRRAVL QAELATESEV PSVLLEAPKD KAHGDFATNI AMQLARIAKK 70 80 90 100 110 120 APRAIAEELV ANFDRKQAGI EKIEIAGPGF INFFLDNGYL RELIPQVLTE KDDYGSSDVG 130 140 150 160 170 180 QGEKVLIEFV SANPTGDLHL GHARGAAVGD TIANIMDKAG YKVSREYYIN DAGNQIENLA 190 200 210 220 230 240 ASLNARYLQV LGEDQPMPED GYHGQDIIDI AKQLVDEAGD QYRQLDEKER LAFMRDYGLK 250 260 270 280 290 300 KELEKIKQDL NAYRVEFDKW FSETSLYESG QVERGLQVLK DKNETYEKDG ATWLRSTAYG 310 320 330 340 350 360 DDKDRVLVKQ DGTYTYLTPD ISYHLDKFDR GHDRLIDVLG ADHHGYIPRM RAAIQALGYD 370 380 390 400 410 420 PARFNVQIIQ MVSLFQGGEK VKMSKRTGKA VTLRELMEEV GVDATRYFFA MRSPDTHLDF 430 440 450 460 470 480 DMDLAVSKSN ENPVYYIQYA HARVCSILRQ GEELGIPYSA NTDLSPIASE KEYELLKAIG 490 500 510 520 530 540 EFPGAVAEAA TKQIPQRIAN YAYDLAQALH SFYNVTRVID TENKDLSAAR LALMKATQMT 550 IKNALALLGV EAPEKM

References

[1]	"The complete genome sequence of the alkaliphilic Bacillus clausii KSM-K16." Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y., Kawai S., Ito S., Horikoshi K. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006627 Genomic DNA. Translation: BAD66426.1.
RefSeq	YP_177387.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5WB34.
Genome annotation databases
GeneID	3201720.
GenomeReviews	Gene locus ABC3895 in contig AP006627_GR.
KEGG	bcl:ABC3895.
NMPDR	fig|66692.3.peg.3870.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5WB34.
OMA	ADHHGYV.
Enzyme and pathway databases
BioCyc	BCLA66692:ABC3895-MON.
Family and domain databases
HAMAP	MF_00123. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BACSK

Accession

Primary (citable) accession number: Q5WB34

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)